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13 March 2018 Photo Edwin Mthimkhulu
Solomon Mahlangu inspires UFS alumnus first Sesotho book
Ace Moloi questions and delves into the concept of freedomin Tholwana Tsa Tokoloho

Tholwana Tsa Tokoloho is the title of Ace Moloi’s anthology of short stories and the name of one of the 14 stories in the book. The anthology is the first book in Sesotho published by the three-time author.

On Friday, 16 March 2018, Tholwana Tsa Tokoloho, an Art Fusion Literature product, will make its debut public appearance during a public reading at the University of the Free State’s Equitas Auditorium at 17:30.

Moloi’s first literary offering was In Her Fall Rose A Nation which was published in 2013 during his final-year as a Communication Science student at the university. In 2016, Moloi published Holding My Breath, which was praised widely for stirring emotions in readers who related to the heart-wrenching narrative of losing a mother. It was only this year that the author managed to achieve his teenage goal of establishing himself as a vernacular author.

Solomon Mahlangu, an African National Congress freedom fighter and Umkhonto we Sizwe militant who was convicted of murder and hanged in 1979, was the inspiration behind the anthology. Mahlangu inspired the Tholwana Tsa Tokoloho story, which is the story of the selflessness of a captured guerrilla hero in the face of police torture and his eventual death by hanging. It represents Mahlangu and those who suffered during the struggle for liberation. 

“My blood will nourish the tree that will bear the fruits of freedom,” are the supposed last words uttered by Mahlangu that inspired the book’s title. Tholwana Tsa Tokoloho means “the fruits of freedom” in Sesotho. For Moloi, writing in the vernacular symbolises the fruits of freedom. “I’m trying to write in a revolutionary spirit, in Sesotho, because we haven’t done that. We have not seriously interrogated political concepts in Sesotho or in any native language,” he said.

Graduate unemployment, violent crime, and sports are some of the other topics tackled in the book. These act as a catalyst for debates over the evidence of ‘the fruits of freedom’ in post-1994 South Africa. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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