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26 February 2019 | Story Eugene Seegers | Photo Eugene Seegers
Prof Francis Petersen, Rector and Vice-Chancellor, Prof Daniella Coetzee, South Campus Principal, Tshegofatso Setilo, Director Access, Prof Prakash Naidoo, Vice-Rector Operations
Prof Francis Petersen, Prof Daniella Coetzee (Principal: South Campus), Tshegofatso Setilo (Head: Access Programmes), and Prof Prakash Naidoo (Vice-Rector: Operations) on the South Campus for the welcoming of first-years.


“Welcome to the South Campus of the University of the Free State!” Addressing a packed Madiba Arena, Prof Francis Petersen, Rector and Vice-Chancellor of the UFS, said he was happy to see not only first-year students, but also parents and guardians, student leadership, and support staff from both the Bloemfontein and South Campuses.

 “I would like to congratulate each of our first-year students for making the decision to come to Kovsies to further your studies here. But I would also like to thank you for making this choice,” he continued.

Prof Petersen further emphasised that the students’ experience and success as individuals are important to the UFS as an institution; therefore, academic and support staff are on hand to guide them through their journey to becoming well-rounded individuals. “We will surely take care of you,” said Prof Petersen. He also reassured parents and guardians that their loved ones would be well looked after.

The Rector also focused attention on the role of student-leadership structures, such as the newly-formed Institutional Student Representative Council (ISRC) and South Campus SRC, members of which were present in the audience. He thanked them for playing a key role in the student constituency, highlighting their support and guidance to help first-years cultivate a sense of belonging at the UFS.

Turning back to first-year students, Prof Petersen stated that they have the unique opportunity to study on a campus specifically focused on developing their full potential, a campus where they can realise their dreams. “Your arrival on the campus marks a new chapter in your life. This chapter is slightly different, as you are the author thereof. The previous chapters in your life were largely written by others—your parents, guardians, families, teachers, and others. You will now be the main author in the next chapter of your unique story.”

“At Kovsies, we believe in developing students in their totality as human beings, not just the academic side. May your time with us equip you to make a success of your life after university!”

Prof Petersen’s Message to First-year Students
  1. Take responsibility for your academic programme.
    • Keep your focus. Study and study hard. You will reap the rewards and see the advantages of making success in your studies a top priority.
    • Make sure that you have enough time for your studies; balance your social life and your time set aside to study.
  2. Realise and remember that you are not alone.
    • If you find things difficult, seek help.
    • Our Department of Student Counselling and Development has trained staff and tailor-made programmes that can assist you.
    • Look after your mental health—and look after each other’s mental health.
  3. Make the most of your time at Kovsies.
    • Join one or more of the student organisations; why not try something new?
  4. Embrace difference and diversity.
    • Get to know students who are different from you.
    • You will lose valuable opportunities to grow if you only associate with your own all the time. It is important to get to know students who are different from you. It could be someone from a different part of the country, or from another country, a different ethnicity, a different religion, someone who has different views from yours, or who has different interests and perspectives.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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