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18 August 2021 | Story André Damons | Photo André Damons
Dr Osayande Evbuomwan is a Senior Lecturer and medical specialist in nuclear medicine in the Department of Nuclear Medicine, Faculty of Health Sciences, at the University of the Free State (UFS).

The University of the Free State (UFS) Department of Nuclear Medicine has, for the first time, started using Lutetium 177 PSMA (Lu-177 PSMA) therapy for the treatment of metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer.

The UFS and the Free State province are now joining other South African universities, such as the University of Pretoria, the University of the Witwatersrand, and other provinces in using this method to treat MCRPC patients. 

Dr Osayande Evbuomwan, a Senior Lecturer and medical specialist in the Department of Nuclear Medicine, Faculty of Health Sciences, says they have started treating their first MCRP patient (first cycle) with peptide receptor radionuclide therapy (PRRT) on 15 July. It is the first time that Lutetium 177 PSMA – a type of PRRT used for treating patients with MCRPC – has been used in the Free State. This method is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Expertise and funds are now available for this treatment

Dr Evbuomwan was trained and exposed to this therapy at the University of the Witwatersrand during his registrar training in nuclear medicine. When he joined the UFS in 2019, he – with the always available help of the Head of Department, Dr Gerrit Engelbrecht – pushed for the therapy to be used in the department. 

“We in the Department of Nuclear Medicine are happy that expertise is now available and that some funds have been released for this treatment to commence. The index patient is very sick with MCRPC and was too sick to qualify for first-line chemotherapy. Each patient will need about four-six cycles for complete treatment. The patient is being treated in the Department of Nuclear Medicine at the Universitas Academic Hospital and Annex.” 

“We are hoping that he will be able to complete at least four cycles and respond well to the treatment. We believe that the ability to administer this treatment now is good news for the Free State, as the people of the Free State also deserve to be exposed to this level of treatment. We are hoping that the government will continue to provide more funds for more of these patients to be treated in our facility,” says Dr Evbuomwan.

It was budgeted to treat five patients (20 cycles), with each cycle (just the Lu-177 PSMA) costing more than R50 000. 

A googled image from the internet of a case before, during, and after completing the full course of therapy. The first image is before
treatment and the last image is after completing treatment, while the images in between are during treatment.
(Source: Google) 

Prostate cancer one of the leading causes of morbidity and mortality

Dr Evbuomwan says prostate cancer is one of the leading causes of morbidity and mortality in the world, including South Africa. When it progresses to the advanced stage of MCRPC, the prognosis becomes bad. 

Dr Evbuomwan explains that there are various conventional systemic therapies, including first- and second-line chemotherapy that could be used to treat patients at this bad stage. However, not all patients are fit for chemotherapy. The few who are fit, according to Dr Evbuomwan, usually end up failing the first-line chemotherapy, which has a lot of undesirable side effects and require long-stay hospital admissions. 

Only a few centres are able to offer second-line chemotherapy. So many of these patients end up suffering from prolonged bone pains before eventually dying from the disease.

PRRT is a targeted nuclear medicine therapy that offers the opportunity to deliver very high levels of radiation specifically to cancer cells, because these cancer cells express specific receptors to which certain peptides can bind. This specificity to cancer cells offers the advantage of providing lower doses of radiation and damage to normal organs and tissues, a characteristic that conventional therapies do not offer, explains Dr Evbuomwan.  

According to him, Lutetium 177 PSMA (Lu-177 PSMA) is a type of PRRT used for treating patients with MCRPC, who are not eligible for chemotherapy or have failed first-line chemotherapy. Numerous research studies around the world have proven that this treatment improves quality of life, slows down disease progression, and improves overall survival, with little or very tolerable side effects in most patients. 

The University of Pretoria is one of the pioneers of this treatment in the world, having done a lot of research with it since 2017. Other provinces such as the Western Cape and KwaZulu-Natal have also recently become involved with the therapy. This therapy is expensive and requires a lot of expertise. It also involves the input of a multidisciplinary team (MDT), which must at least include a nuclear medicine physician, a radiation oncologist, and a urologist. The Departments of Urology and Radiation Oncology at the UFS were also instrumental in the initiation of the therapy and form part of the MDT team at the UFS in the management of these patients.

Treatment puts department, university, and hospital on the map

Dr Evbuomwan says the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. “It also creates an avenue for us to gather data for research purposes and for publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients no longer need to travel to other provinces to get the treatment.”

There are plans to expand the treatment to more patients – and hospital management, who were present at the first treatment, are excited and looking forward to the outcome of this current treatment.

Watch video below:

News Archive

UFS hosts the biggest HIV/AIDS event in its history
2007-10-05

The Chief Directorate: Community Service at the University of the Free State (UFS), in partnership with the Free State Department of Education, will host the biggest HIV/AIDS focus event in the history of the university.

The event will take place on Wednesday, 10 October 2007 on the Main Campus in Bloemfontein and the theme will be: Management of HIV/AIDS in the Workplace.

According to the Chief Director of Community Service at the UFS, the Rev Kiepie Jaftha, this event forms part of a wider role of his directorate to raise the level of awareness about the impact of HIV/AIDS within the university and the higher education sector in South Africa. It will also enhance the executive management’s buy-in and ownership of this role and incorporate the flow of HIV/AIDS information and activities into the core business of the UFS.

The focus will be on getting the executive management, middle management, aspiring managers and those who are affected by the decisions of the management, on board in the university’s endeavour to manage and create HIV/AIDS awareness in the workplace.

Most importantly, community members will also form an essential part of this event as the UFS strives to get them also involved in HIV/AIDS education and awareness.

“We hope to release the valve of denialism and stir the excitement amongst people, to encourage them to get involved in creating awareness within their workplaces, institutions and society,” said the Rev Jaftha.


To that effect, the Director of the Africa Centre for HIV/AIDS Management at the University of Stellenbosch, Prof. Jan du Toit, will deliver a keynote address. There will also be a mini-musical production called Lucky, the Hero, directed by the well-known stage performer and director of Educational Theatre and creative arts for the Africa Centre for HIV/AIDS Management, Prof. Jimmie Earl Perry.

The 25 tables for the event have been sold at a cost of R1 500 each and the beneficiaries thereof will be a local non-governmental organization (NGO), namely the Lebone Land Care Centre. The UFS has a long-standing relationship with the Lebone Land Care Centre, where students are sent as part of the implementation of their community service learning modules to enhance their practical skills. Now the university intends to formalise this partnership.

“I admire the holistic manner of approach the Lebone Land Care Centre uses towards caring for people who are infected and affected by HIV/AIDS and the way they make people realise that they can still live a meaningful life and add dignity and value to society,” enthused Rev Jaftha.

The NGO will also receive an award from Spar, one of the biggest supermarket groups in South Africa.

Media Release
Issued by: Mangaliso Radebe
Assistant Director: Media Liaison
Tel: 051 401 2828
Cell: 078 460 3320
E-mail: radebemt.stg@mail.ufs.ac.za
04 October 2007
 

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