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08 February 2021 | Story André Damons | Photo Charl Devenish
Prof Mamello Sekhoacha, Associate Professor from the Department of Pharmacology in the Faculty of Health Sciences, was appointed by Dr Zweli Mkhize, Minister of Health, as the new chairperson of the National Health Research Ethics Council of South Africa (NHREC).

A researcher in the field of drug discovery and development at the University of the Free State (UFS) has been appointed by Dr Zweli Mkhize, Minister of Health, as the new chairperson of the National Health Research Ethics Council of South Africa (NHREC).

Prof Mamello Sekhoacha, Associate Professor from the Department of Pharmacology in the Faculty of Health Sciences, was appointed as a member of the NHREC council in 2013, and later became the chairperson of the NHREC’s Norms and Standards Committee responsible for developing and revising guidelines for health research. Prof Sekhoacha was appointed deputy chairperson of the council in 2018 and has played an integral part in setting ethical standards for conducting health research in the country.

 Responsibilities of the NHREC

The NHREC is the national statutory body responsible for the governance and advancement of health research ethics in South Africa. Some of the responsibilities of the council are to set ethical norms and standards for health research by developing and revising the guidelines pertaining to health research; to promote and monitor compliance with existing regulations by health research ethics committees; and to build capacity in research ethics committees through robust registration and audit processes.

These responsibilities of the NHREC rest on the need to ensure ethical integrity in research involving human participants and animal subjects, and that research is based on sound scientific and ethical principles.

“It is an honour for me to serve on the NHREC for the third term. The NHREC has achieved remarkable outputs over the past three years, and I believe, given the current composition of the council members, this momentum will not be lost. One of the goals of the NHREC is to further broaden the scope of the ethics in health research guidelines from ‘biomedical research’ to ‘health-related research’ to ensure that adequate guidance is provided for those in health-related disciplines, as a response to the changing environment of research involving humans and the broader meaning of health research.” 

“We need more comprehensive guidelines with nuanced commentaries to indicate how the ethical principles that emanated from biomedical research involving humans, could be effectively implemented in other disciplines of health-related research,” says Prof Sekhoacha. 

Global paradigm shift in role and integration of ethics in health research

Having been a council member since 2013, Prof Sekhoacha, whose training spans from pre-clinical laboratory experimentation, the use of animals in research, clinical trials, and working with indigenous communities, says there is a global paradigm shift in the role and integration of ethics in health research in almost all aspects of research, with an increased emphasis on the scientific and social value of research: the prospect of generating the knowledge in a manner that protects and promotes people's health. Considerations of the NHREC go beyond developing ethical guidelines or ensuring the efficient functioning of the ethics committees, to raising awareness among research institutions and researchers to continually promote ethically sound research conduct. 

The subject of ethics in health research is pivotal and reflective of the values of both the institution and the country at large. 

UFS uses Prof Sekhoacha’s expertise on ethics

Prof Sekhoacha is also a co-opted advisory member in the Senate Research Ethics Committee of the UFS and facilitates workshops and seminars on research ethics offered by the Postgraduate School.

Prof Corli Witthuhn, Vice-Rector: Research and Internationalisation, says it is a great honour for the UFS that Prof Sekhoacha has been elected chair of the NHREC.  “The NHREC governs the research ethics processes in South Africa, and it is strategically important for the UFS to now have one of our own academics play such a nationally important role.  We have been using Prof Sekhoacha’s expertise on issues of ethics and we are looking forward to working with her to continue to better our own ethics processes.”

News Archive

Science is diversifying the uses of traditional medicines
2017-07-17

Description: Dr Motlalepula Matsabisa  Tags: traditional medicines, Indigenous Knowledge Systems, Dr Motlalepula Matsabisa, Malaria, priority disease  

Dr Motlalepula Matsabisa.
Photo: Anja Aucamp

According to the World Health Organisation, a large majority of the African population are making use of traditional medicines for health, socio-cultural, and economic purposes. In Africa, up to 80% of the population uses traditional medicines for primary healthcare.

The Indigenous Knowledge Systems (IKS) was identified as a lead programme under the directorship of Dr Motlalepula Matsabisa. Research undertaken by the IKS Lead Programme focuses on some key priority diseases of the country and region – including malaria, HIV, cancer, and diabetes.
 
Not just a plant or tree

Malaria is a priority disease and is prevalent in rural and poor areas, resulting in many traditional health practitioners claiming to treat and cure the disease. There may well be substance to these claims, since as much as 30% of the most effective current prescription medicines are derived from plants.  For instance, chloroquine, artemisinin for malaria, Metformin for diabetes, Vincristine and Vinblastine for cancer, are plant-derived drugs.  

Dr Matsabisa’s current research is investigating a South African medicinal plant that has been shown to have in vitro antiplasmodial activity, with subsequent isolation and characterisation of novel non-symmetrical sesquiterpene lactone compounds offering antimalarial activity. These novel compounds are now patented in South Africa and worldwide. This research is part of the UFS and South Africa’s strive to contribute to the regional and continental malaria problem. The UFS are thus far the only university that has been granted a permit by the Medicines Control Council to undertake research on cannabis and its potential health benefits.

“All of these projects are aimed
at adding value through the scientific
research of medicinal plants, which
can be used for treating illnesses,
diseases, and ailments.”

Recognition well deservedThrough Dr Matsabisa’s research input and contributions to the development of the pharmacology of traditional medicines, he recently became the first recipient of the International Prof Tuhinadrin Sen Award from the International Society of Ethnopharmacology (ISE) and the Society of Ethnopharmacology in India. ISE recognises outstanding contributions by researchers, scientists, and technologists in the area of medicinal plant research and ethnopharmacology internationally.

More recently, Dr Matsabisa undertook research projects funded by the National Research Foundation, as well as the Department of Science and Technology, on cancer, gangrene, and diabetes. He is also involved in a community project to develop indigenous teas with the community. He says, “All of these projects are aimed at adding value through the scientific research of medicinal plants, which can be used for treating illnesses, diseases, and ailments”.

Dr Matsabisa has worked with many local and international scientists on a number of research endeavours. He is grateful to his colleagues from the Department of Pharmacology in the Faculty of Health Sciences, who are dedicated to science research and the research of traditional medicines. The IKS unit also received immense support from the Directorate of Research Development.

 

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