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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

International Bible scholars attend conference on Apocalyptic Literature and Mysticism
2017-09-18

Description: Bible Scholars Tags: Bible Scholars, UFS Faculty of Theology and Religion, Prof Francis Petersen 

Prof Francis Petersen, UFS Rector and Vice-Chancellor,
second from left, flanked by three
deans of theology: Prof Fanie Snyman (UFS),
Prof Jörg Frey (University of Zurich),
and Prof Gregory Sterling (Yale Divinity School).
Photo: Eugene Seegers


Apocalypticism and mysticism have become two key areas of research that have converged to form the heart of contemporary spirituality. It was with this in mind that leading local and international Bible scholars were invited to a collaborative international conference jointly hosted by the UFS Faculty of Theology and Religion and Yale Divinity School, with the theme Apocalyptic Literature and Mysticism—Investigating a Turn in Recent Apocalyptic Research.

It is perhaps unknown to many that a number of the most profound thinkers, both of Judeo-Christian tradition and other religions in general, were mystics. Their lives and writings speak of a longing for an intimate relationship with God, reflecting on universal existential questions such as understanding our human existence, our creation, and ultimately, the meaning of life.

Apocalypticism, on the other hand, focuses on texts and prophecies describing how an alternative, future world might replace our existing one, a process often cataclysmic in nature, thus, like the mystics, also reflecting on the deeper foundations of human existence and our possible demise.

Traditionally, both have been misunderstood and controversial, but more recent research has revealed their formative role in religious discourses, with many scholars finding growing commonalities between apocalyptic and mystical texts. Moreover, these commonalities help to establish a better understanding of Judeo-Christian traditions, as well as other religions in general.

This hugely successful UFS collaborative effort, as well as others of its kind, contribute to the growth of theology as a discipline, with a positive impact on the broader religious community, the church, and society as a whole in the common desire for a just, equitable, and humane world.

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