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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

Africa the birthplace of mathematics, says Prof Atangana
2017-11-17


 Description: Prof Abdon Atangana, African Award of Applied Mathematics  Tags: Prof Abdon Atangana, African Award of Applied Mathematics

Prof Abdon Atangana from the UFS Institute for Groundwater Studies.
Photo: Supplied

 

Prof Abdon Atangana from the Institute for Groundwater Studies at the University of the Free State recently received the African Award of Applied Mathematics during the International conference "African’s Days of Applied Mathematics" that was held in Errachidia, Morocco. Prof Atangana delivered the opening speech with the title "Africa was a temple of knowledge before: What happened?” The focus of the conference was to offer a forum for the promotion of mathematics and its applications in African countries.

When Europeans first came to Africa, they considered the architecture to be disorganised and thus primitive. It never occurred to them that Africans might have been using a form of mathematics that they hadn’t even discovered yet.

Africa is home to the world’s earliest known use of measuring and calculation. Thousands of years ago Africans were using numerals, algebra and geometry in daily life. “Our continent is the birthplace of both basic and advanced mathematics,” said Prof Atangana. 

Africa attracted a series of immigrants who spread knowledge from this continent to the rest of the world.

Measuring and counting
In one of his examples of African mathematics knowledge Prof Atangana referred to the oldest mathematical instrument as the Lebombo bone, a baboon fibula used as a measuring instrument, which was named after the Lebombo Mountains of Swaziland. The world’s oldest evidence of advanced mathematics was also a baboon fibula that was discovered in present-day Democratic Republic of Congo.

Another example he used is the manuscripts in the libraries of the Sankoré University, one of the world’s oldest tertiary institutions. This university in Timbuktu, Mali, is full of manuscripts mainly written in Ajami in the 1200s AD. “When Europeans and Western Asians began visiting and colonising Mali between the 1300s and 1800s, Malians hid the manuscripts in basements, attics and underground, fearing destruction or theft by foreigners. This was certainly a good idea, given the Europeans' history of destroying texts in Kemet and other areas of the continent. Many of the scripts were mathematical and astronomical in nature. In recent years, as many as 700 000 scripts have been rediscovered and attest to the continuous knowledge of advanced mathematics and science in Africa well before European colonisation. 

Fractal geometry

“One of Africa’s major achievements was the advanced knowledge of fractal geometry. This knowledge is found in a wide aspect of Africa life: from art, social design structures, architecture, to games, trade and divination systems. 

“The binary numeral system was also widely known through Africa before it was known throughout much of the world. There is a theory that it could have influenced Western geometry, which led to the development of digital computers,” he said. 

“Can Africa rise again?” Prof Atangana believes it can.

He concluded with a plea to fellow African researchers to do research that will build towards a new Africa.

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