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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

SRC Reunion - 2005
2004-12-02

Dear Ex-SRC Member
Reunion 2005


The University of the Free State (UFS) is celebrating it centenary with the theme 100+. This celebration does not only focus on the past, but especially on the future for the next 100 years. The conclusion of the Centenary year will be held on 28 January 2005 together with Kovsie Day, a joint project with the UFS Centenary Festival, Student Representative Council and Rag, and includes a huge “Potjiekos” Festival. This closing function is, however, the beginning of the future festival which reaches its climax from 4–6 February 2005. During the weekend, an SRC Reunion will be held to which all ex-SRC members are personally invited.

The weekend program briefly includes the following:

Friday, 4 February 2004

09:00 Official opening of the University with a message by the Vice-Chancellor and Rector, prof. Frederick Fourie

11:00 A massive campus photo of all on campus

19:00 Through the night together with Rag.

Saturday, 5 February 2004

08:30 Champagne breakfast at the Thakaneng Bridge

10:00 Official attendance of the Rag Procession

19:00 SRC Dinner at the Centenary Festival Complex

Sunday, 6 February 2005

18:30 A special combined Dedication service at the Red Square (Rooiplein).

It will be a great privilege for the UFS to welcome all SRC members of the past 100 years. RSVP no later than 14 January 2005 to Nicolaas du Plessis. The costs will be indicated on the RSVP form.

N.B.: The UFS would be pleased to reach all ex-members. Should you be in contact with any other members, please send this information to them or contact me at the necessary contact numbers. For more information please contact me at 084 955 0875 or Elize Rall at 051-401 3382.

Please fax the RSVP form no later than 14 January 2004 to Nicolaas du Plessis at 051-447 7344 of e-mail information to: duplessisnf.rd@mail.uovs.ac.za

Nicolaas du Plessis

SRC Officer

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