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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

Unique programme for next generation of professors launched
2010-11-19

Some of the scholars taking part in the Vice-Chancellor's Prestige Young Scholars Programme are, from the left: Dr Andréhette Verster, Ms Liezel Kotzé and Dr Nthabeleng Rammile.
Photo: Stephen Collett

The University of the Free State (UFS) has launched a programme that will provide an accelerated pathway to 25 young scholars with recent PhDs and teach them how to become professors through intensive local and international mentorship, research support and academic training.

The Vice-Chancellor’s Prestige Programme for Young Scholars focuses on the next generation of top researchers in South Africa who will fill the gap left by retiring academics. It will also add significantly to the diversity of the professoriate at the UFS.

No other university in the country has a programme of such scale and intensity for building excellence and diversity through young scholars.

“The programme is highly selective and limited to the most promising young scholars at the university. It will also contribute towards establishing an international reputation for the university and positioning the UFS as one of the best research institutions in the country,” said Prof. Neil Roos, Director of the Postgraduate School at the UFS. He will manage the programme together with Prof. Jackie du Toit, also from the university.

Running for the next three years, the programme will put the 25 scholars through an intensive programme of academic and scholarship support which includes advanced theoretical and methodological training and exposure to leading international scholars in their fields. They will also be exposed to intensive reading and writing programmes, high-level seminar and conference participation and presentation, accelerated publication schedules and personal mentoring and advising plans.

“Scholarship will only grow if there is a critical mass – and this is what we want to achieve at the UFS. We want to create a pool of young scholars, develop and connect them with international scholars and place them at top universities in the world where they can be mentored by the best in their respective fields,” said Prof. Jonathan Jansen, Vice-Chancellor and Rector of the UFS at the launch of the programme.

According to Prof. Jansen, the UFS aims to draw public intellectuals and A-rated scientists to the campus and make academic work attractive to academics at the university and countrywide.

The group of scholars has a good academic record, with 69% of them completing their PhDs within the last five years. The group is well represented in terms of race and gender; the majority are in the 26 to 30-year age group and specialisations include the social sciences (including education, the humanities and arts) as well as the natural sciences.

“Scholarship develops over time. We are proud and extremely honoured to be selected for this prestigious programme. With this scholarship we acknowledge the responsibility of building the UFS and of extending our knowledge across disciplines. We will establish a scholarly advancement for our university that will enable it to compete with the best in the world,” said Dr Nalize Marais, one of the prestige scholars.

The launch was also attended by members of the university’s International Advisory Council (IAC). This council, which visited the university the past week to advise the leadership on its future positioning strategies, especially in relation to its international aspiration to become a place of scholarship and service among the leading universities in the world, congratulated the UFS on this groundbreaking programme.

“You are lucky to have a leadership that dares to dream and that can act the dream. You are fortunate that your leadership wants to take this university forward and explore new horizons,” said Prof. Aki Saweyrr, former Secretary-General of the Association of African Universities in Ghana and member of the IAC.

Ending the evening’s programme was Dr Gansen Pillay, Vice-President of the National Research Foundation. Prof. Gansen also congratulated the UFS on its visionary and inspirational leadership. “It is a privilege to make a life-changing contribution to research in the world. Universities must take ownership of their own development – which is exactly what the UFS is doing. And, although this is a truly South African programme, it could have an impact on the rest of the world,” he said.
 

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