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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

Additional and ad hoc examinations as well as results
2017-01-11

Additional Examination

Additional examinations will be arranged for students who are unable to write the main examination during the period 24 November 2016 to 14 December 2016 (excluding the Faculty of Health Sciences).
 
The additional examinations will take place from 4 January 2017 to 16 January 2017.
Application forms are available at the Examination Department and online at KovsieLife.

Closing date for all additional examination applications: 14 December 2016.
The Examination Department will notify students of the outcome via e-mail.
 
Procedure:
•    Completed applications will be handed in at the Examination Department.
•    The Examination Department will notify students of the outcome via e-mail.
•    Students must refer to the official examination timetable for their personal timetable.

For more information, please contact Anneline Dyers on dyersaf@ufs.ac.za
 

Ad hoc Examinations

Ad hoc examinations will be arranged for students who are unable to write the main and additional examinations in the periods 24 November to 14 December and 4 January 2017 to 16 January 2017, respectively (excluding the Faculty of Health Sciences).

 
The ad hoc examinations will take place from 23 to 27 January 2017.
Application forms are available at the Examination Department.

Closing date for all ad hoc applications: 14 December 2016.
The Examination Department will notify students of the outcome via e-mail.
 
Procedure:
•    Completed applications must be handed in at the Examination Department.
•    The Examination Department will electronically send applications, including supporting documents, to the respective deans and the Registrar (Governance) for approval.
•    The Examination Department will notify students of the outcome via e-mail.
•    The Examination Department will arrange a venue for the examinations.

For more information, please contact Alfredine Majiedt on majiedtay@ufs.ac.za


Results

Provisional examination results for the main and additional examinations will be posted onto a student’s record seven (7) working days after the relevant examination. Should students require their provisional results, they may access it via Self-Service on KovsieLife.
 
Official examination results will only be available on 1 February 2017.

For more information, please contact Edwin Crouch on crouchej@ufs.ac.za

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