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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

UFS congratulates Free State on matric results
2017-01-05

 Description: 002 IBP Matric results Tags: 002 IBP Matric results

With projects like the Internet Broadcast Project and the
Schools Partnership Projects the UFS helps to improve
education at schools in the Free State.
Photo: iStock

The University of the Free State (UFS) congratulates the Free State and its learners on their outstanding performance in the 2016 matric results. The university, who also plays a role in promoting excellence at school level, is proud of the Free State’s achievement as the best-performing province in the country with a 93,2% pass rate, excluding progressed learners.

“On behalf of the university community I would like to congratulate the Free State MEC of Education, Tate Makgoe, who is also a member of the UFS Council, and the Department of Education in the province on this fine achievement. The UFS is proud to be involved in projects that contribute to the success of the province’s learners. These include the Internet Broadcast Project (IBP) and the Schools Partnership Projects (SPP). The projects help to improve the quality of teaching and help learners to overcome severe domestic conditions in rural areas,” says Prof Nicky Morgan, Acting Vice-Chancellor and Rector of the UFS.

Internet Broadcast Project

The UFS IDEAS Lab in the Department of Open and Distance Learning on the UFS South Campus supports learners in 83 schools through the IBP with the help of academic videos. The project is a collaboration between the university and the Department of Education in the province. It includes support for subjects such as Mathematics, Physical Science, Life Science, Economics, Accounting, and Geography.

A purpose-built school appliance, comprising a projector, speakers, and a PC, is set up at each school, where learners receive video lectures from highly-qualified teachers.

During a function held in Bloemfontein on 5 January 2017 to congratulate performing schools in the province, Mr Makgoe made special mention of the IBP and said that part of the success of the province can be attributed to the project. Many of the top performing schools had learners who participated in the project. One of the districts that forms part of the project, the Xhariep District, was announced as the top performing district in the province, and is second in the country.


Schools Partnership Projects

The SPP focuses on teachers in order to have a more sustainable impact, with 69 schools in the Free State and Eastern Cape being part of it.

It makes use of mentors (30) who assist teachers and headmasters with school management, Mathematics, Physical Science, Accounting, and English as language of learning. The project has an annual budget of more than R15 million – all the funds come from sponsors outside the UFS.

Mentors visit schools and share knowledge, extra material, and technology to improve the standard of teaching. The change has been significant. Matric results and Bachelors pass rates have improved dramatically in these schools.

Another aspect is the identification of learners with potential (so-called first-generation students) to go to university. They are assisted through extra classes and in applying for tertiary education and bursaries.

Many of them currently study at the UFS, and also receive mentorship at university.

Dr Peet Venter, SPP Project Manager, said his team is proud to be part of the process of helping the Free State to become the number one province in the country again.

Both the IBP and SPP was started in 2011 and are managed from the university’s South Campus in Bloemfontein.

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