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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

The King’s Singers: British double Grammy winners hosted by OSM
2017-01-24

 Description: The Kings Singers Tags: The Kings Singers

The King’s Singers regularly tour in Europe, North and
South America, Asia and Australasia. The group will be
performing in Bloemfontein on 14 February 2017.
Photo: Andy Staples

The King’s Singers, the acclaimed British a cappella vocal ensemble, are coming to Bloemfontein, hosted by the Odeion School of Music at the University of the Free State, for an unmissable performance.

Concertgoers from Bloemfontein and surrounding areas have the opportunity to experience this extraordinary vocal ensemble at the Dutch Reformed Church Universitas at a concert sponsored by the Arts Trust.

Named after King’s College in Cambridge, the group was formed in 1965, and for the past 48 years, their work, synonymous with the very best in vocal ensemble performance, appeals to a vast international audience.

The ensemble has performed for hundreds of thousands of people each season, and regularly tours Europe, North and South America, Asia and Australasia. Instantly recognisable for their immaculate intonation, vocal blend, diction and incisive timing, the King’s Singers are consummate entertainers.

The group’s repertoire has evolved to become one of the most diverse and compelling imaginable. They have commissioned more than 200 works, including landmark pieces from leading contemporary composers including Luciano Berio, György Ligeti, Sir James MacMillan, Krzysztof Penderecki, Toru Takemitsu, Sir John Tavener, Gabriela Lena Frank and Eric Whitacre. They have also commissioned arrangements of everything from jazz standards to pop chart hits, explored medieval motets and Renaissance madrigals, and encouraged young composers to write new scores.

In addition to performing to capacity audiences and creating highly regarded and much-loved recordings, the King’s Singers share their artistry at numerous workshops and masterclasses around the world.  

Double Grammy award-winning artists, the group were honoured in 2009 for their Signum Classics release, Simple Gifts, and again in 2012 for their contribution to Eric Whitacre’s Light and Gold album. Recently voted into Gramophone Hall of Fame, rave reviews and repeated sell-out concerts confirm that the King’s Singers are one of the world’s finest vocal ensembles.

Watch videos of the The King’s Singers:
The King's Singers - Overture The Barber Of Seville
2016 Pioneer Day Concert with The King's Singers - Primary Medley
A Christmas Songbook by The King's Singers

Date: 14 February 2017
Time: 19:30
Place: Dutch Reformed Church Universitas, Bloemfontein
Cost: R295 per person | R268 per person for group bookings of 10+

Tickets for the concert are available at Computicket outlets (Checkers, Shoprite shops), at the door, or online.

For inquiries or more information, contact Ninette Pretorius at +27 51 401 2504.

 

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