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30 August 2022 | Story André Damons | Photo André Damons
UFS Nuclear Medicine
The team of doctors in the Department of Nuclear Medicine behind the success story are, from the left (standing): Dr Osayande Evbuomwan, nuclear medicine specialist and Senior Lecturer; Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS; and Dr Walter Endres, nuclear medicine registrar. In front is Dr Tebatso Tebeila, nuclear medicine registrar.

The University of the Free State (UFS) Department of Nuclear Medicine is proud to announce the successful treatment outcome of a patient with metastatic castrate-resistant prostate cancer (MCRPC) – an advanced stage of prostate cancer – by using Lutetium 177 PSMA (Lu-177 PSMA) therapy. This was initially a case of advanced stage prostate cancer, which had failed first-line chemotherapy, leaving little or no other treatment options.

This is a proud and happy moment for the department and the UFS, which started this treatment just over a year ago. The university and the Free State province are now joining other South African medical universities, such as the University of Pretoria, and other provinces in using this method to treat MCRPC patients. Lutetium 177 PSMA (Lu-177 PSMA) therapy is used on MCRPC patients who are not eligible for chemotherapy or have failed first- or second-line chemotherapy.

Dr Gerrit Engelbrecht, Clinical Head of the Department of Nuclear Medicine at the UFS, says the department is proud to be able to offer this treatment option to some of these patients. “It is a big win for the Free State and our oncology patients to be able to offer these expert services.” The UFS and Universitas Academic Hospital have now been able to join up with other academic institutions and hospitals in other provinces to offer these services. So far, three patients have been offered this therapeutic option, with the third patient currently undergoing his treatment.

Funds and equipment for proper treatment selection are needed

The expertise is no longer an issue for the UFS, as Dr Osayande Evbuomwan, nuclear medicine specialist and consultant, was trained and exposed to this therapy at the University of the Witwatersrand during his training as a nuclear medicine resident. Current registrars in the Department of Nuclear Medicine at the UFS are also being trained in the application of this treatment modality. However, proper patient selection is key in the management of these cases with Lu 177 PSMA. Without a PET/CT camera, it is challenging to appropriately select the patients who are most likely to respond to this therapy. This is an example of how PET/CT is crucial in the management and monitoring of oncology patients.

Both Drs Engelbrecht and Evbuomwan hope that the training of more registrars will increase their department’s capacity to treat more patients. They also hope that funds will be made available to acquire a much-needed PET/CT camera, which will greatly assist them in identifying the correct patients in need of this treatment. 

With the permission of the patient, the images above show the dramatic treatment response following Lu-177 PSMA therapy. The images on the left show widespread bone disease from the prostate cancer, including the skull. The images on the right show the dramatic response after completing four cycles of Lu 177 PSMA, with the normal excretion of the radiotracer seen in the liver, kidneys, and bladder.


Treatment puts the department, UFS, and hospital on the map

According to Dr Evbuomwan, the ability to administer this treatment puts the department, the UFS, and the hospital on the map, alongside other top universities within and outside the country. Says he: “It also creates an avenue for us to gather data for training, research purposes, and publications. We are now able to offer a promising, safe, and highly efficacious therapy for patients with MCRPC in the Free State. Some of these patients will no longer have to travel to other provinces to receive this treatment.”


“We are also well aware that not every patient will respond this way; however, proper patient selection is key in identifying responders – an area that is still being researched. We also do not know how long these patients will have their disease under control after the treatment. Nuclear medicine’s greatest cancer therapy success story is the treatment of well-differentiated thyroid cancer with radioactive iodine.” 

“After treatment, most of these patients remain cancer-free for a very long period of time, if not for life. With continuing research in the field of MCRPC radioligand therapy, we aim to improve the treatment modality, hopefully getting it to the success level of thyroid cancer therapy.”

 

News Archive

UFS Council elects new Chairperson
2017-01-27

Description: Mr Willem Louw and Nthabeleng Rammile Tags: Mr Willem Louw and Nthabeleng Rammile

Mr Willem Louw, new Chairperson of the Council
of the University of the Free State, and Dr Nthabeleng
Rammile, new Vice-Chairperson.
Photo: Stephen Collett

The Council of the University of the Free State (UFS) elected Mr Willem Louw as the new Chairperson during a special meeting on Friday 20 January 2017. He was Vice-Chairperson of the Council since 13 March 2015. Dr Nthabeleng Rammile was elected Vice-Chairperson at the same meeting, making her the first woman in the history of the university elected to this position.

The election of Mr Louw comes after the announcement by Justice Ian van der Merwe at a Council meeting on 2 December 2016 that he will be stepping down as Chairperson on 31 December 2016.

Mr Louw has served on the Council since 11 September 2009 and was elected as member of the Executive Committee of the Council on 18 November 2011. He furthermore serves on the Council’s subcommittees for Audit and Risk Management, and Honorary Degrees.

In accepting his election as Chairperson, Mr Louw said that he appreciates the trust Council has bestowed on him. “It is a privilege and honour to lead Council and I look forward to the challenge. With the support of Dr Rammile and the rest of the Council, I endeavour to ensure that the university management is assisted in the governance of the university and that the Council plays its governance role fully at all times,” he said.

“The UFS is privileged to have Mr Louw and Dr Rammile leading its Council at such a crucial time in the South African higher-education sector. Their combined experience will be of great benefit to the university community,” said Prof Nicky Morgan, Acting Vice-Chancellor and Rector of the UFS.

Mr Louw is an Associate of the Transnet Centre for Business Management of Projects at the University of Stellenbosch Business School and a non-executive Director of Group Five Limited. He was previously Managing Director of the technology business unit and a member of Group Management at Sasol, where he worked from 1985 until 2011. He is a member of the South African Council for the Project and Construction Management Professions and a Fellow of the South African Academy of Engineering. Mr Louw received his Bachelor’s and Master’s degrees in Civil Engineering from Stellenbosch University and his MDP (Management Development Programme in Project Management) from UNISA. He is currently enrolled for a PhD in Business Management and Administration at the University of Stellenbosch Business School.

Dr Rammile has served on the Council as representative of the religious communities since 1 January 2016. She is also member of the Council subcommittees for Audit and Risk Management, and Naming. She obtained a PhD in Brand Management at the UFS, where she also lectured in the Department of Business Management from 2003 to 2014. She is a pastor at Global Reconciliation, where she is responsible for women’s ministry, community outreach projects, and multimedia.

Mr Louw will serve as Chairperson of Council until 31 December 2018, and Dr Rammile will serve as Vice-Chairperson until 12 March 2018.

Released by:
Lacea Loader (Director: Communication and Brand Management)
Telephone: +27 51 401 2584 | +27 83 645 2454
Email: news@ufs.ac.za | loaderl@ufs.ac.za
Fax: +27 51 444 6393

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