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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

UFS intensifies its advocacy on humanity and solidarity to Japan

2011-03-08

Staff and students from our university, marching for humanity
Photo: Stephen Collett

Staff and students from the University of the Free State (UFS) representing various associations and student bodies, together with Kovsie supporters, braved the cold and wet weather yesterday (17 March) as they embarked on a march for humanity. This occurred just two days after an urgent meeting had been called by the Dean of Student Affairs, Mr Rudi Buys to create a platform for students to deliberate on mechanisms to be used in supporting Japan, which is facing immense challenges, thereby responding to their unfortunate current situation. It is also a day after the direct conversation between the UFS and the South African ambassador to Japan, Mr Gert Grobler, a Kovsie alumnus.

The visibly spirited group started their march from the Main Building on the UFS Main Campus in Bloemfontein. Within minutes the Callie Human Centre – assembly point for the participants – was occupied by students and staff members who arrived in their numbers, carrying banners with messages of support for Japan.

Modieyi Motholo, ISC Chairperson, read a memorandum in the presence of more than 300 students. “We, the community of the University of the Free State, as sons and daughters of South Africa and the world, by our very action in this march today, celebrate our shared humanity, declare our solidarity with the people of Japan, and join the movement to build a culture of Human Rights. We declare our commitment to the cause of human dignity and equality, and the promotion of human rights, non-racialism and non-sexism,” read the memorandum.

“Japan is far; we shall never be able to take the entire Kovsie community there to assist the Japanese in rebuilding their homes. However, we can show our solidarity and raise an awareness for their unfortunate circumstances by our numbers,” Modieyi said.

Mr Buys admitted to being overwhelmed by the united Kovsie community he witnessed standing up for a cause they believed in. On receiving the memorandum on behalf of the UFS management, he stated: “There is a different and new set of values in our student community. We have the best students in the world, driven by a pioneering spirit aimed at building a new society. We have come so far in a short period of time. You deserve recognition as a student population.”

The march was also organised to declare the UFS’s support and solidarity for the people of Japan. The solidarity campaign has further been intensified with the establishment of committees comprising fundraising, research, marketing and awareness, spirituality and volunteers. Nida Jooste, the ISC Vice-Chairperson, said that the research committee was busy conducting a comprehensive study on how the UFS can be of assistance to the Japan. “With the report we will be able to design and implement programmes that will be aligned with the needs of the people of Japan. “In the meantime, we will carry out small projects that will keep the flame of solidarity burning on our campus,” she concluded.

Noticeable amongst the attendees were Mr John Samuels, the current Director of the International Institute for Studies in Race, Reconciliation and Social Justice.

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