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11 July 2022 | Story Andre Damons | Photo Supplied
Prof Martie Smith and Prof Drik Opperman
Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin. 

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products.  This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.  

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.  

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.  

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties. 

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows. 

The two funds are: 

1.  The Industrial Engagement Fund 
2.  The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:



News Archive

UFS hosts first SA Digital Sky Academy at the Naval Hill Planetarium
2015-10-02


From the left are: Prof Neil Heideman
(Dean: Faculty of Natural and Agricultural Sciences, UFS),
Jack White (Director: Sky-Skan Oceania),
Dr Michelle Cluver (Department of Astronomy, University of the Western Cape),
Martin Ratcliffe (Director: Professional Development, Sky-Skan).
Photo: Mart-Mari Duvenhage

South Africa hosts some of the world’s largest telescopes, and won the bid to co-host the SKA recently. So it’s not surprising that there is unprecedented interest in Astronomy in our country. Astronomy is seen as a gateway subject that attracts people to the sciences, while planetariums help to make Astronomy accessible to millions of people.  Digital planetariums are especially powerful teaching tools because they are versatile, offer an immersive experience, and explain and illustrate three-dimensional concepts effectively.  On the other hand, scientists, are eager to exploit a digital planetarium’s potential to represent and explore data visually, whether the data relate to medicine, astronomy, chemistry, the environment, or other fields of research.

The four-day ‘Digital Sky Academy’ (DSA) presented at the Naval Hill Planetarium in Bloemfontein from 18 - 22 September 2015 was an opportunity to offer training and first-hand experience of digital planetarium technology to representatives from other centres in South Africa. The Department of Physics at the University of the Free State (UFS) was the host of this event.

The Department of Science and Technology has designated the Naval Hill Planetarium as the South African hub for the training of digital planetarium presenters and operators. In addition to attracting interest from scientists and future planetarium operators and presenters, the DSA workshop provided an invaluable opportunity for our presenters to hone their skills.

A number of experienced and distinguished people attended the workshop. Among them was Dr Mark SubbaRao from Chicago in the United States, who shared information on data visualisation techniques used in the Adler Planetarium. Jack White, Director of Sky-Skan, one of the few companies that provide digital technology for planetariums throughout the world, coordinated the event in partnership with Prof Matie Hoffman from the Department of Physics at the UFS.

Jack travelled from Melbourne in Australia to oversee the workshop. Two Sky-Skan colleagues from the United States, Martin Weiss and Martin Ratcliffe, were on hand to share their expertise on digital planetarium hardware and software. The workshop programme included Skype conference calls with other US-based planetarium experts. Amongst the delegates to the DSA representatives from the SKA, the Iziko Museum, and five South Africa universities. They were here to gain experience, explore the capacity of the digital facility, and share ideas on future collaboration.

During the workshop, a public lecture was held on 19 September. Dr Michelle Cluver from the University of the Western Cape gave a presentation entitled, ‘More than the eye can see: the significance of infrared light in Astronomy.’

 

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