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UFS busy with exciting research into flavours and fragrances

11 July 2022 | Story Andre Damons | Photo Supplied

Prof Martie Smith and Prof Drik Opperman — Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

Flavours and fragrances have a wide application in the food, feed, cosmetic, chemical and pharmaceutical sectors. Many flavour compounds are still produced via chemical synthesis or via extraction from plant or animal sources. However, there is increasing interest in their bio-production or the use of flavour compounds of (micro) biological origin.

One reason for this shift is that chemical synthesis often uses environmentally unfriendly processes. Chemical synthesis usually also produces racemic mixtures with the second enantiomer, mirror image of the looked-for compound, often having undesirable organoleptic properties. Furthermore, the consumer has developed a “chemophobia”-attitude towards synthetic chemical compounds, especially when related to food and home-care products. This applies even to nature-identical compounds – products that occur in nature but are produced via a non-natural chemical process. Products produced with the use of enzymes or microbes from “natural” substrates can be labelled “natural”. The flavour and fragrance industry thus pay higher prices for such products labelled as “natural”.

The invention

A University of the Free State (UFS) team, led by Prof Martie Smit and Prof Dirk Opperman in the Department of Microbiology and Biochemistry are conducting exciting research in this area. They filed a patent entitled “Process for the chemical modification of alkanes, fatty acids and fatty alcohols”.

The invention relates to a process for the enzymatic in-chain hydroxylation of C12 to C16 fatty acids, alcohols, and alkanes. Hydroxylation of C12 fatty acid and alcohol provides routes for the synthesis of “natural” δ-dodecalactone. The advantage of these routes is that they do not rely on massoia lactones. Massoia lactones are derived from the bark of Massoia trees which grow in Indonesia. Harvesting of the bark kills the trees.

The cytochrome P450 enzymes (P450s) claimed in this patent are to the inventors’ knowledge the most regioselective enzymes described thus far that can be used for the synthesis of δ-dodecalactone from lauric acid or 1-dodecanol. The approach that the technology takes is to claim cytochrome P450 enzymes that share 70 % amino acid identity to a set of selected P450s for the regioselective hydroxylation of lauric acid and 1-dodecanol to synthesise δ-dodecalactone.

Still in early stage

The current state of development is early stage with the technology only demonstrated in the laboratory on a small scale (100-200 ml). Before the technology can be commercialised the team would need to further improve the regioselectivity and stability of the P450s and proof that the reactions can be scaled up in bioreactors. The technology will probably be delivered as an enzyme (amino acid sequence) with the desired properties.

There are other research groups working on a synthetic biology approach for the de novo synthesis of δ-dodecalactone from glucose by genetically engineered microbes. It is still unclear how such a process will compare in terms of product yields, economics and environmental impact with the processes proposed by the UFS patent.

If the team had to partner with a commercial company, their first choice would be to work with an established flavour and fragrance company. Another possibility would be the small French flavour and fragrance company that Dr Alizé Pennec, the post-doc and co-inventor who initially discovered the unique P450 activity, is working for.

Please view the videos for more information on patents.

The Vice-Rector: Research and Internationalisation has released two new calls for applications for funding. Academic staff and researchers are encouraged to submit applications for these funds. At this stage we are not accepting projects from Research Fellows.

The two funds are:

1. The Industrial Engagement Fund

2. The Intellectual Property Commercialisation Fund

Each fund has its own guidelines and application process. The guidelines are attached. The applications must be filled in on RIMS.

The RIMS application forms can be found through this link

For more information please click the documents below:

IP Commercialisation Fund Concept Note

The UFS Industry Engagement Fund Concept Note

News Archive

Khayalami residence launches first in-house library

2016-04-21

Description: 2016 KL News Khayalami library Tags: Khayalami residence launches first in-house library in the country
Bongani Mtotoba (left) and Sinoxolo Gcilitshana (right) at the first-ever 24 hour in-house library at Khayalami residence. The librarian and Deputy Residence Head respectively hope to revive the culture of reading on our Bloemfontein Campus.
Photo: Valentino Ndaba

“It is said that reading means to the brain what exercise means to the body. For that reason, we want to bring back the culture of reading to our students who are, after all, the future replacement of the leadership of our wounded and broken country,” said Sinoxolo Gcilitshana, Deputy Residence Head, and Prime of Khayalami.

Titles such as A Life Ever Lasting by Miranda Hearn, To Live Free by William Wilberforce, Powers of Darkness Powers of Light by John Cornwell, and Character Counts by Charles Dyer are among the 228 inspirational books on the shelves of Khayalami residence’s library. Tuesday 12 April 2016 was a proud moment for the residence as it launched the first library in the country located within a university residence on the Bloemfontein Campus of the University of the Free State.

Last year, Dimpho Jasa, a resident at Khayalami, approached Sinoxolo, who then held the Residence Committee (RC): Academics portfolio, with an idea of forming a book club. Sinoxolo had suggested that a library be established in order to make the book club sustainable. That conversation served as a foundation of the 24 hour in-house library.

“We started with five books last year,” said Sinoxolo, “and ever since we sent the message out, the Vice-Chancellor and Rector, Prof Jonathan Jansen has been supporting us together with the Vice-Rector, Prof Nicky Morgan, as well as the Dean of the Faculty of Education, Prof Sechaba Mahlomaholo, and the Head of the Department of English, Prof Helene Strauss.”

Now, more than 170 young men have access to a growing library that is expected to hold 1500 books by September, when Sinoxolo steps down as the Prime. According to Bongani Mtotoba, the RC: Academics and librarian, some residents have made pledges to help expand the collection. “The response has been quite positive from the guys,” he said.

Borrowers are required to submit a book review upon returning the book. This feedback will be compiled by the English Department into a book available to the public.

Khayalami’s pioneering spirit has also seen the residence run a successful writing competition in 2015. It has since been introduced to the rest of the East College, and now will take place annually.

For more information on how to donate books or enter the writing completion, contact Sinoxolo on 0783332203 or semsinoxolo@hotmail.com.

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