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24 October 2022 | Story Andrè Damons | Photo Monsoon Photography
Prof Paul Oberholster
Prof Paul Oberholster was one of 29 scholars and scientists that were inaugurated as new ASSAf members in earlier this month (19 October 2022).

Prof Paul Oberholster, Director of the Centre for Environmental Management at the University of the Free State (UFS), is the newest academic from the university to be inaugurated as a member of the Academy of Science of South Africa (ASSAf). 

Prof Oberholster was one of 29 scholars and scientists who were inaugurated as new ASSAf members earlier this month (19 October 2022). At the same time, 10 new members of the South African Young Academy of Science (SAYAS) were inaugurated.

As the official Academy of South Africa, ASSAf honours the country’s most outstanding scholars by electing them to membership of the Academy. ASSAf members are drawn from the full spectrum of disciplines. New members are elected each year by the full membership of the Academy in recognition of scholarly achievement. Members are the core asset of the Academy and give of their time and expertise voluntarily in the service of society. The 29 new ASSAf Members bring the total membership of ASSAf to 659.

Science must be in the service

“I feel very honoured to have been selected as a member of the official national academy of science which represents South Africa in the international community of science academies. I am a strong believer that science must be in the service of society. In all my research, I have shown an interest and determination to bring practitioners, students, and scholars together to pursue and foster the betterment of the human condition through its intimate relation to the natural world. The latter is in strong relationship with the vision and mission of the Academy,” says Prof Oberholster about being included in the academy of science.

This honour comes almost a year after Prof Oberholster won the NSTF-Water Research Commission (WRC) Award for his contribution to water resource management in SA over the past five years, with special reference to the field of biological passive wastewater treatment.

According to him, the ASSAf membership means providing evidence-based scientific advice on water resource issues of public interest to government and other stakeholders. He was nominated by Prof Eugene Cloete, the previous Vice-Rector Research and Innovation at Stellenbosch University for his research focus related to water resource management.

Research has direct impact on the most important resources

Prof Corli Witthuhn, Vice Rector: Research and Internationalisation, says the UFS staff and students are proud of the national recognition that Prof Oberholster received for his lifetime achievements in research on water resource management. His research has direct impact on the managing, protection and rehabilitation of one of the country’s most important resources.  

“The demands on our water supplies will increase in the future as a result of climate change globally. We believe his research will become even more important and relevant in the next decade. We are looking forward to his future achievements and will work with him to provide him with the appropriate UFS support.  Congratulations,” says Prof Witthuhn.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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