Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
24 October 2022 | Story Andrè Damons | Photo Monsoon Photography
Prof Paul Oberholster
Prof Paul Oberholster was one of 29 scholars and scientists that were inaugurated as new ASSAf members in earlier this month (19 October 2022).

Prof Paul Oberholster, Director of the Centre for Environmental Management at the University of the Free State (UFS), is the newest academic from the university to be inaugurated as a member of the Academy of Science of South Africa (ASSAf). 

Prof Oberholster was one of 29 scholars and scientists who were inaugurated as new ASSAf members earlier this month (19 October 2022). At the same time, 10 new members of the South African Young Academy of Science (SAYAS) were inaugurated.

As the official Academy of South Africa, ASSAf honours the country’s most outstanding scholars by electing them to membership of the Academy. ASSAf members are drawn from the full spectrum of disciplines. New members are elected each year by the full membership of the Academy in recognition of scholarly achievement. Members are the core asset of the Academy and give of their time and expertise voluntarily in the service of society. The 29 new ASSAf Members bring the total membership of ASSAf to 659.

Science must be in the service

“I feel very honoured to have been selected as a member of the official national academy of science which represents South Africa in the international community of science academies. I am a strong believer that science must be in the service of society. In all my research, I have shown an interest and determination to bring practitioners, students, and scholars together to pursue and foster the betterment of the human condition through its intimate relation to the natural world. The latter is in strong relationship with the vision and mission of the Academy,” says Prof Oberholster about being included in the academy of science.

This honour comes almost a year after Prof Oberholster won the NSTF-Water Research Commission (WRC) Award for his contribution to water resource management in SA over the past five years, with special reference to the field of biological passive wastewater treatment.

According to him, the ASSAf membership means providing evidence-based scientific advice on water resource issues of public interest to government and other stakeholders. He was nominated by Prof Eugene Cloete, the previous Vice-Rector Research and Innovation at Stellenbosch University for his research focus related to water resource management.

Research has direct impact on the most important resources

Prof Corli Witthuhn, Vice Rector: Research and Internationalisation, says the UFS staff and students are proud of the national recognition that Prof Oberholster received for his lifetime achievements in research on water resource management. His research has direct impact on the managing, protection and rehabilitation of one of the country’s most important resources.  

“The demands on our water supplies will increase in the future as a result of climate change globally. We believe his research will become even more important and relevant in the next decade. We are looking forward to his future achievements and will work with him to provide him with the appropriate UFS support.  Congratulations,” says Prof Witthuhn.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept