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28 June 2024 | Story André Damons | Photo André Damons
Prof Victor Houliston
Prof Victor Houliston, Research Professor in the Department of English, is an A-rated researcher at the University of the Free State (UFS).

The University of the Free State (UFS) has added another National Research Foundation (NRF) A1-rated researcher to its ranks with the appointment of Prof Victor Houliston, Research Professor in the Department of English. This brings the number of the university’s A1-rated researchers to three.

The university also boasts the first A2 rating in the field of arts in the person of Prof Willem Boshoff, a senior professor in the Department of Fine Arts within the Faculty of The Humanities and one of South Africa's foremost contemporary artists. The other scholars with an A1 rating are Prof Maxim Finkelstein, the distinguished Professor at the Department of Mathematical Statistics and Actuarial Science, and Prof Melanie Walker, Distinguished Research Professor and National Research Foundation (NRF) Chair in Higher Education and Human Development.

The A rating is for researchers regarded as world leaders in their fields. Prof Houliston received his rating in 2022 – three years after retiring from the University of the Witwatersrand (Wits).

Consistent research output

Prof Houliston, who is an authority on early modern British and Irish Catholic studies (religion and politics) and has also published on John Donne (especially his prose works and sermons) and Renaissance rhetoric, says there is no formula for receiving an A1 rating.

“The definition of an A-rated scholar is someone who has achieved a certain reputation in their field internationally. That comes from a consistent research output, building up a portfolio of work in a particular field and moving the debate along, so that you become the go-to person on that subject.

“There is that sense of focus and some shifting of the picture or debate or understanding in your field. In science, the evaluation of a person's standing is more straightforward; in the humanities, research has a more subjective element so one's work is more vulnerable to criticism. In my case, as my research has evolved from English literature into historical studies, it has entailed archival and linguistic groundwork which makes it a little more objective,” says Prof Houliston.

The importance of Robert Persons

It is hard to say whether he chose his specialism, or his specialism chose him: an unexpected request for help from Guy Butler in 1988 led to his investigating the life and career of Robert Persons, an English Jesuit from the time of Queen Elizabeth I. Over the intervening 30 years, this Catholic activist has become widely recognised as one of the most important figures in early modern European history.

Prof Houliston started with a re-interpretation of Persons' published works, culminating in a 2007 monograph, Catholic Resistance in Elizabethan England. He is now editing Persons' extensive multilingual correspondence, as the leader of an international team of experts. The second volume was published earlier this year, with a third in preparation. He is also working with a team of South African classicists to translate Persons' Latin publications.

"As with most research, we work from the known to the unknown, pushing back further into the primary material – the archive."

Prof Houliston says that as a researcher, one must jealously guard one's time, which is difficult because the demands of teaching and administration have become more burdensome. Most academics show great commitment and idealism when it comes to teaching, so they are reluctant to leave students to their own devices. Ironically, this often leads those who are on the A-rating trajectory to take refuge in specialised institutes or centres of excellence and stop teaching, which can be a loss to students.

Given space to do research 

“Lecturers at a university such as the UFS, with its goal of increasing its research productivity, need space to do research. Bureaucracy may have to retract a bit. Lecturers themselves have to learn where to draw the line,” he says.

"This may appear selfish, but it enhances the learning environment. If you were to ask students if they preferred to be in a university where high-quality research is taking place, they would likely say, 'Yes. That gives my degree greater credibility. I would want to feel that those who are teaching me are contributing to the increase of knowledge’.”

His advice to emerging researchers is to follow the advice of Stephen Covey, author of The 7 Habits of Highly Effective People: conduct a weekly review of how they are managing to integrate research into their daily life as academics. Most lecturers are in a position where they only do research during vacations, but they can challenge themselves to carve out more regular times for research.

No slowing down

“That idea of constant review is important so that you are always moving forward. Many people just give up, because research is more challenging than, say, answering your emails, and you need energy and time. So, if you can reduce that start-up cost by doing a little every day, and preferably at the beginning of every day, it will make all the difference.

“The UFS, and especially heads of departments, can help to create a culture where scholars and researchers feel part of an interactive community. We need to move beyond the system to a sense of vocation. We have a vocation as university lecturers, professors and scholars, and everything else is secondary to the pursuit of knowledge. The system is merely a tool,” says Prof Houliston.

With multiple large-scale research projects on the go, as well as workshops and writing retreats, he is now busier than ever, with no plans for slowing down. He says: “I recently hosted a workshop for colleagues planning to apply for rating, to optimise their applications. One of my briefs is to enhance the research communities within the English department and the Faculty of Humanities in general, and especially amongst younger researchers.”

You could say he is speeding up. He recently completed a master’s degree in creative writing. "It's never too late to discover how many bad writing habits I have developed over the years!" 

News Archive

Research contributes to improving quality of life for cancer patients
2016-11-21

Description: Inorganic Chemistry supervisors  Tags: Inorganic Chemistry supervisors

Inorganic Chemistry supervisors in the Radiopharmacy
Laboratory during the preparation of a typical complex
mixture to see how fast it reacts. Here are, from the left,
front: Dr Marietjie Schutte-Smith, Dr Alice Brink
(both scholars from the UFS Prestige
Scholar Programme), and Dr Truidie Venter (all three
are Thuthuka-funded researchers).
Back: Prof André Roodt and Dr Johan Venter.
Photo: Supplied

Imagine that you have been diagnosed with bone cancer and only have six months to live. You are in a wheelchair because the pain in your legs is so immense that you can’t walk anymore – similar to a mechanism eating your bones from the inside.

You are lucky though, since you could be injected with a drug to control the pain so effective that you will be able to get out of the wheelchair within a day-and-a-half and be able to walk again. Real-life incidents like these provide intense job satisfaction to Prof André Roodt, Head of Inorganic Chemistry at the University of the Free State (UFS). The research, which is conducted by the Inorganic Group at the UFS, contributes greatly to the availability of pain therapy that does not involve drugs, but improves the quality of life for cancer patients.

The research conducted by the Inorganic Group under the leadership of Prof Roodt, plays a major role in the clever design of model medicines to better detect and treat cancer.

The Department of Chemistry is one of approximately 10 institutions worldwide that conducts research on chemical mechanisms to identify and control cancer. “The fact that we are able to cooperate with the Departments of Nuclear Medicine and Medical Physics at the UFS, the Animal Research Centre, and other collaborators in South Africa and abroad, but especially the methodology we utilise to conduct research (studying the chemical manner in which drugs are absorbed in cancer as well as the time involved), enhances the possibility of making a contribution to cancer research,” says Prof Roodt.

Technique to detect cancer spots on bone
According to the professor, there are various ways of detecting cancer in the body. Cancer can, inter alia, be identified by analysing blood, X-rays (external) or through an internal technique where the patient is injected with a radioactive isotope.

Prof Roodt explains: “The doctor suspects that the patient has bone cancer and injects the person with a drug consisting of an isotope (only emits X-rays and does no damage to tissue) that is connected to a phosphonate (similar to those used for osteoporosis). Once the drug is injected, the isotope (Technetium-99m) moves to the spot on the bone where the cancer is located. The gamma rays in the isotope illuminate the area and the doctor can see exactly where treatment should be applied. The Technetium-99m has the same intensity gamma rays as normal X-rays and therefore operates the same as an internal X-ray supply.” With this technique, the doctor can see where the cancer spots are within a few hours.

The same technique can be used to identify inactive parts of the brain in Alzheimer patients, as well as areas of the heart where there is no blood supply or where the heart muscle is dead.

Therapeutic irradiation of cancer
For the treatment of pain connected with cancer, the isotope Rhenium-186 is injected. Similar to the manner in which the Technetium-99m phosphonate compound is ingested into the body, the Rhenium-186 phosphonate travels to the cancer spots. Patients thus receive therapeutic irradiation – a technique known as palliative therapy, which is excellent for treating pain. A dosage of this therapy usually lasts for about two months.

The therapy is, however, patient specific. The dosages should correspond with the occurrence and size of cancer spots in the patient’s body. First, the location of the cancer will be determined by means of a technetium scan. After that, the size of the area where the cancer occurs has to be determined. The dosage for addressing total pain distribution will be calculated according to these results.

Technique to detect cancer spots on soft tissue
Another technique to detect cancer as spots on bone or in soft tissue and organs throughout the body is by utilising a different type of irradiation, a so-called PET isotope. The Fluor-18 isotope is currently used widely, and in Pretoria a machine called a cyclotron was produced by Dr Gerdus Kemp, who is a former PhD graduate from the Inorganic Research Group. The F-18 is then hidden within a glucose molecule and a patient will be injected with the drug after being tranquillised and after the metabolism has been lowered considerably. The glucose, which is the ‘food' that cancer needs to grow, will then travel directly to the cancer area and the specific area where the cancer is located will thus be traced and ‘illuminated’ by the Fluor-18, which emits its own 'X-rays'.

In the late 80s, Prof Roodt did his own postdoctoral study on this research in the US. He started collaborating with the Department of Nuclear Medicine at the UFS in the early 90s, when he initiated testing for this research.

Through their research of more than 15 years, the Inorganic Group in the Department of Chemistry has made a major contribution to cancer research. Research on mechanisms for the detection of cancer, by designing new clever chemical agents, and the chemical ways in which these agents are taken up in the body, especially contributes to the development in terms of cancer therapy and imaging, and has been used by a number of hospitals in South Africa.

The future holds great promise
Prof Roodt and his team are already working on a bilateral study between the UFS and Kenya. It involves the linking of radio isotopes, as mentioned above, to known natural products (such as rooibos tea), which possess anti-cancer qualities.

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