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26 November 2024 | Story Leonie Bolleurs | Photo Supplied
SARIMA presentations 2024
The UFS DRD team that attended and presented at the 2024 SARIMA conference in Maputo, Mozambique.

The Directorate Research Development (DRD) team from the University of the Free State (UFS) joined research management professionals from across the globe at the 2024 Southern African Research and Innovation Management Association (SARIMA) Conference held in September this year. This year's conference, hosted for the first time in Mozambique, focused on the theme, It Takes a Village to Raise a Child, highlighting the collective effort needed in research and innovation.

The UFS delegation participated in workshops on navigating change, unlocking research impact potential, tools and techniques for research and innovation project management, reviewing research-related contracts, and assessing associated risks. The Bill and Melinda Gates Foundation also led a training session, while other workshops explored strengthening global research partnerships and advancing competencies in research management.

Opportunity to share and learn about best practices

Boemo Segoje, Officer for RIMS, Ethics and Creative Outputs, reflected on the conference’s collaborative atmosphere, noting the opportunity to share and learn about best practices. Segoje, alongside Maricel van Rooyen, Senior Officer: Project Manager, RIMS and Ethics, presented a poster titled, Empower the Village with an Effective Research Management System, showcasing the university’s InfoEd Research Information Management System (RIMS). “Our audience was particularly impressed with how RIMS consolidates various research functions into one platform,” said Segoje.

Another UFS poster by Mpho Mashamba, Officer: RIMS Development and Maintenance, and Ethics and Katleho Nyaile from the Centre for Graduate Support (CGS) focused on Breaking Down Silos: Enhancing Interdepartmental Communication in Research Administration. They highlighted the need for collaboration within the university, emphasising how interdepartmental communication enhances research outcomes. “We referred to the importance of collaborating with other units, keeping a line of communication open, as well as engaging various stakeholders. This is especially important for a team like ours whose work impacts every faculty member,” said Mashamba.

Mandy Jampies, Senior Officer Postdoctoral Fellows presented on It Takes a Village: Fostering Collaborative Networks for Postdoctoral Fellow Management. This talk focused on building a ‘village’ for postdoctoral fellows by streamlining visa processes and establishing partnerships with other institutions, such as the University of Johannesburg. "The audience showed great interest in our initiatives, particularly the visa partnership with the Department of Home Affairs," Jampies remarked.

Jampies’s commitment to supporting postdoctoral fellows extended beyond her presentation. In addition to discussing ways to build a supportive ‘village’ through streamlined visa processes and collaborative partnerships, she also played a role in the science communication pre-conference workshop. Reflecting on this workshop, Jampies noted it as a standout moment. “Boemo Segoje and I had the chance to present on the university’s initiatives to boost research visibility through newsletters, social media and webinars,” she shared.

Sugan Moodley, Director of Research Development Finance, remarked that it was interesting to see the Research Management progression made by universities and to compare similarities, differences, strengths and weaknesses between the UFS and other universities.

AI, here to stay

Mashamba found inspiration in a session by the University of Ghana, where he drew parallels between Ghana’s research fund and the UFS Central Research Fund. “Learning from their experience will help enhance our processes here at the university,” he shared. A big fan of lifelong learning, he saw the conference as a great opportunity to pick up new ideas. He said, "I really made the most of every moment. For me, a few key things stood out. First off, having clear policies and standard operating procedures (SOPs) is important for making things run smoothly and getting more done.”

He continued, “As for AI, it’s definitely here to stay. I’m excited about the potential AI has to help streamline our work. Once it’s ready to be used effectively in the workplace, I’d love to bring it into our systems and even use it to improve what we’re already doing." Additionally, Dr Glen Taylor, the Director of Research Development at the UFS, expressed similar enthusiasm for the AI presentation, finding it an interesting insight into the future of research processes.

For Segoje, the conference also highlighted the importance of leadership in research management, referring to a session by the University of Pretoria on Ubuntu leadership. “The emphasis on Ubuntu aligns with the UFS’s values, emphasising the importance of sharing knowledge and empowering others,” she said.

Reflecting on the conference, Jampies concluded, “SARIMA 2024 was one of the best conferences I have attended, providing a wealth of practical knowledge that I can apply to improve my work portfolio.”

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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