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16 September 2024 | Story André Damons | Photo Supplied
Dr Mampoi Jonas and Prof Jan Du Plessis
Dr Mampoi Jonas, senior lecturer in Paediatric Oncology and Prof Jan Du Plessis, Head of the Paediatric Oncology Unit at the University of the Free State (UFS).

A campaign like Childhood Cancer Awareness Month is vital in creating awareness and educating people about the early signs and symptoms of certain cancers. This can significantly improve the survival rate of young patients. More than 50% of people diagnosed with cancer live for more than five years, and some types of cancer have survival rates as high as 90%.

This is according to Prof Jan Du Plessis, Head of the Paediatric Oncology Unit, and Dr Mampoi Jonas, senior lecturer in Paediatric Oncology, at the University of the Free State (UFS).

“Early diagnosis is crucial because early-stage cancer is more responsive to treatment and less likely to be fatal. Due to the rarity of childhood cancer, many children get misdiagnosed or diagnosed too late with advanced stage disease. The delayed detection and diagnosis diminish the chances of successful treatment.

“Cancer awareness educates families, communities, primary-care nurses and doctors about the early signs and symptoms of certain cancers. When people are aware of these, they are more likely to be on the lookout for them when children present with suspicious clinical symptoms and signs. This also gives parents the confidence to seek help early and even make people better able to support those with the disease once a diagnosis is made,” say the paediatric oncologists.

Recorded incidences on the rise

Though childhood cancer is rare, representing only 1.2% of all cancers worldwide, the recorded incidences are increasing. In the US cancer is the number one cause of death among children, while more than 100 000 children worldwide die because of cancer.

Prof Du Plessis says there are more than 12 major types of childhood cancers and multiple subtypes. The most common types are leukaemia, lymphoma (tumours that begin in the lymph glands), brain tumours, nephroblastoma (cancer of the kidneys) and soft tissue sarcomas. Most cancers in children are thought to develop as a result of mutations in genes that lead to uncontrolled cell growth and eventually cancer.

According to Dr Jonas, most cancers in children are thought to develop because of mutations in genes that lead to uncontrolled cell growth and eventually cancer. Although environmental pollutants have been implicated in some cancers, our experience has been that most paediatric cancers rather occur sporadically.

The reasons for the increase of reported incidence of cancer in children, could be to the increase in population numbers and better awareness of childhood cancers. Another reason might be that more children are being diagnosed who were previously misdiagnosed, explains Prof Du Plessis.

Treatments

Childhood cancers are treated with chemotherapy, surgery and radiation therapy under the care of a paediatric oncologist. Not much can be done about the genetic mutations, but parents can ensure that their children stay safe in the sun (slip, slop, slap campaign – slip on a shirt, slop on some suncream and slap on a hat), get their children vaccinated against HPV infection, help their children stay active and keep a healthy weight and talk to them about smoking.

Prof Du Plessis says the South African paediatric oncology community are currently busy with a few research studies regarding standardising treatment protocols for certain childhood cancers. This is to find out how our children are responding to these protocols and to see if there are different factors affecting the outcomes of South African children. These protocols are based on international treatment protocols with a few adjustments for local circumstances and resources.

They are involved with the Hodgkins lymphoma, neuroblastoma, retinoblastoma, germ cell tumour studies and contributed to a research study evaluating the nutritional status and interventions to improve the nutritional status of local patients. Registrars presented local (Bloemfontein) data at an international conference (SIOP Africa) on hepatoblastomas and osteosarcomas.

“For many childhood cancer may not be a priority or something they would like to think about. Unfortunately for many of my patient’s parents the truth is that the day before their children were diagnosed with cancer, they were also not a cancer parent. However, their lives changed for ever with these four words: ‘Your child has cancer’.

“Childhood cancer is more than chemo and no hair. It is rather about resilience, strength, hope, family, courage, cuddles, and bravery. Your life will be changed for ever if you have ever seen a child fight cancer. Their smiles will make your heart melt and make you realise the importance of the simple things in life,” declare Prof Du Plessis and Dr Jonas.

Early warning signs for parents

The Childhood Cancer Foundation South Africa (CHOC) has a campaign which emphasises the importance of recognising the early warning signs of childhood cancer. They use Siluan’s Early Warning Signs to raise awareness and promote early diagnosis which are:

• S – Seek medical help early for ongoing symptoms
• I – White spot in the eye, new squint, sudden blindness or bulging eyeball.
• L – Lump on the stomach, pelvis, head, arms, legs, testicle, or glands
• U – Unexplained fever present for over two weeks, weight loss, fatigue, pale appearance, easy bruising, and bleeding
• A – Aching bones, joints, back, and easy fractures

• N – Neurological signs, a change in walk, balance or speech, regression, continuous headaches with/without vomiting, and an enlarged head

While these symptoms can be subtle or easily attributed to other causes, it’s important to consult a doctor if they persist or worsen. If you notice any of these symptoms in a child or teen, seek professional medical help promptly. Early detection of cancer saves lives in both children and teens.

News Archive

SA-YSSP scholars attend high level colloquium with policy makers and research stakeholders
2014-02-12

From the left are: Prof Frans Swanepoel, Deputy-Director of the African Doctoral Academy, Drs Aldo Stroebel, Executive Director: International Relations and Cooperation at the National Research Foundation, Priscilla Mensah, co-director of the SA-YSSP, and Ulf Dieckmann from the International Institute for Applied Systems Analysis and Dean of the SA-YSSP.
Photo: Renè-Jean van den Berg

Scholars taking part in the 2nd Southern African Young Scientists Summer Programme (SA-YSSP), attended a one-week seminar hosted by the African Doctoral Academy at the Stellenbosch University, which concluded with a colloquium at the Stellenbosch Institute for Advanced Study.

This was part of the final leg of their three-month stay and studies at the University of the Free State.

This seminar was a capacity development intervention with the purpose of equipping SA-YSSP young scholars with the skills to communicate their research work effectively with different audiences.

The 36 scholars were hand-picked from some of the world’s most promising and top researchers to take part in the novel three-month programme for advanced doctoral candidates. Their research interests closely aligned with the Department of Science and Technology’s (DST) grand challenges and the International Institute for Applied Systems Analysis’ (IIASA) current research programmes regarding global environmental, economic and social change.

The SA-YSSP is an initiative that contributes to the establishment, growth and enhancement of high-level strategic networks internationally. At the same time it develops capacity in systems analysis at the PhD and supervisory levels through research conducted in the areas of the Department of Science and Technology’s (DST) grand challenges.

At the colloquium, students were expected to showcase their work and research according to their various fields of expertise. High-profile policy makers and policy funders, as well as academia and fellow researchers judged and critiqued the work.

Dr Priscilla Mensah from the UFS and co-director of the programme, says it is important for the young scientists to frame their findings in a way that will be relevant to policy makers and the public at large.

“The partnership with the African Doctoral Academy was crucial in this regard since it is a capacity development entity aimed at strengthening and advancing doctoral education, training and scholarship on the African continent. The objective of this week-long capacity strengthening intervention is to equip the young scientists to be able to communicate their research effectively with different audiences, including potential funders and policy makers.

“I am convinced that the young scientists will no longer view policy makers as abstract entities, but as stakeholders who must be engaged to facilitate implementation of evidence-based policy.”

Dr Aldo Stroebel, Executive Director: International Relations and Cooperation, National Research Foundation, says the purpose of the colloquium is to bring together different sectors in one room to look at different challenges holistically, with an emphasis on systems analysis for a common goal.

The SA-YSSP forms part of an annual three-month education, academic training and research capacity-building programme jointly organised by IIASA, based in Austria, the National Research Foundation (NRF) and the DST. IIASA is an international research organisation that conducts policy-oriented scientific research in the three global problem areas of energy and climate change, food and water, and poverty and equity. South Africa’s engagements with IIASA, specifically with regard to the SA-YSSP, relate primarily to the DST’s Ten-Year Innovation Plan.

The UFS is the first institution outside Austria to host the summer programme. Researchers in the programme are, among others, from South Africa and the rest of the African continent, the USA, the Netherlands, India, Hungary, Austria and Germany.

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