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16 September 2024 | Story André Damons | Photo Supplied
Dr Mampoi Jonas and Prof Jan Du Plessis
Dr Mampoi Jonas, senior lecturer in Paediatric Oncology and Prof Jan Du Plessis, Head of the Paediatric Oncology Unit at the University of the Free State (UFS).

A campaign like Childhood Cancer Awareness Month is vital in creating awareness and educating people about the early signs and symptoms of certain cancers. This can significantly improve the survival rate of young patients. More than 50% of people diagnosed with cancer live for more than five years, and some types of cancer have survival rates as high as 90%.

This is according to Prof Jan Du Plessis, Head of the Paediatric Oncology Unit, and Dr Mampoi Jonas, senior lecturer in Paediatric Oncology, at the University of the Free State (UFS).

“Early diagnosis is crucial because early-stage cancer is more responsive to treatment and less likely to be fatal. Due to the rarity of childhood cancer, many children get misdiagnosed or diagnosed too late with advanced stage disease. The delayed detection and diagnosis diminish the chances of successful treatment.

“Cancer awareness educates families, communities, primary-care nurses and doctors about the early signs and symptoms of certain cancers. When people are aware of these, they are more likely to be on the lookout for them when children present with suspicious clinical symptoms and signs. This also gives parents the confidence to seek help early and even make people better able to support those with the disease once a diagnosis is made,” say the paediatric oncologists.

Recorded incidences on the rise

Though childhood cancer is rare, representing only 1.2% of all cancers worldwide, the recorded incidences are increasing. In the US cancer is the number one cause of death among children, while more than 100 000 children worldwide die because of cancer.

Prof Du Plessis says there are more than 12 major types of childhood cancers and multiple subtypes. The most common types are leukaemia, lymphoma (tumours that begin in the lymph glands), brain tumours, nephroblastoma (cancer of the kidneys) and soft tissue sarcomas. Most cancers in children are thought to develop as a result of mutations in genes that lead to uncontrolled cell growth and eventually cancer.

According to Dr Jonas, most cancers in children are thought to develop because of mutations in genes that lead to uncontrolled cell growth and eventually cancer. Although environmental pollutants have been implicated in some cancers, our experience has been that most paediatric cancers rather occur sporadically.

The reasons for the increase of reported incidence of cancer in children, could be to the increase in population numbers and better awareness of childhood cancers. Another reason might be that more children are being diagnosed who were previously misdiagnosed, explains Prof Du Plessis.

Treatments

Childhood cancers are treated with chemotherapy, surgery and radiation therapy under the care of a paediatric oncologist. Not much can be done about the genetic mutations, but parents can ensure that their children stay safe in the sun (slip, slop, slap campaign – slip on a shirt, slop on some suncream and slap on a hat), get their children vaccinated against HPV infection, help their children stay active and keep a healthy weight and talk to them about smoking.

Prof Du Plessis says the South African paediatric oncology community are currently busy with a few research studies regarding standardising treatment protocols for certain childhood cancers. This is to find out how our children are responding to these protocols and to see if there are different factors affecting the outcomes of South African children. These protocols are based on international treatment protocols with a few adjustments for local circumstances and resources.

They are involved with the Hodgkins lymphoma, neuroblastoma, retinoblastoma, germ cell tumour studies and contributed to a research study evaluating the nutritional status and interventions to improve the nutritional status of local patients. Registrars presented local (Bloemfontein) data at an international conference (SIOP Africa) on hepatoblastomas and osteosarcomas.

“For many childhood cancer may not be a priority or something they would like to think about. Unfortunately for many of my patient’s parents the truth is that the day before their children were diagnosed with cancer, they were also not a cancer parent. However, their lives changed for ever with these four words: ‘Your child has cancer’.

“Childhood cancer is more than chemo and no hair. It is rather about resilience, strength, hope, family, courage, cuddles, and bravery. Your life will be changed for ever if you have ever seen a child fight cancer. Their smiles will make your heart melt and make you realise the importance of the simple things in life,” declare Prof Du Plessis and Dr Jonas.

Early warning signs for parents

The Childhood Cancer Foundation South Africa (CHOC) has a campaign which emphasises the importance of recognising the early warning signs of childhood cancer. They use Siluan’s Early Warning Signs to raise awareness and promote early diagnosis which are:

• S – Seek medical help early for ongoing symptoms
• I – White spot in the eye, new squint, sudden blindness or bulging eyeball.
• L – Lump on the stomach, pelvis, head, arms, legs, testicle, or glands
• U – Unexplained fever present for over two weeks, weight loss, fatigue, pale appearance, easy bruising, and bleeding
• A – Aching bones, joints, back, and easy fractures

• N – Neurological signs, a change in walk, balance or speech, regression, continuous headaches with/without vomiting, and an enlarged head

While these symptoms can be subtle or easily attributed to other causes, it’s important to consult a doctor if they persist or worsen. If you notice any of these symptoms in a child or teen, seek professional medical help promptly. Early detection of cancer saves lives in both children and teens.

News Archive

nGAP lecturers welcomed by the UFS academic community
2016-06-30

Description: nGAP lecturers group photo Tags: nGAP lecturers group photo

University of the Free State’s newly-appointed nGAP
lecturers. From the left, Neo Mathinya,
Phumudzo Tharaga, and Kelebogile Boleu.

The University of the Free State (UFS) was allocated six positions as part of the Department of Higher Education and Training (DHET) New Generation of Academics Programme (nGAP). Four candidates have filled positions in the Faculty of Health Sciences, Faculty of the Humanities and the Faculty of Natural and Agricultural Sciences – with two positions still vacant.

According to Minister of Higher Education and Training, Dr Blade Nzimande, nGAP is part of the Staffing South Africa's Universities Framework, which focuses on the expansion of the size and compilation of academic staff at South African universities, especially with regard to transformation. The focus of the programme is the appointment of black and coloured candidates as well as women.

The Department of Soil, Crop, and Climate Sciences in the Faculty of Natural and Agricultural Sciences welcomed two nGAP lecturers, Phumudzo Tharaga and Neo Mathinya. The Faculty was allocated four positions. Two positions are filled, while two positions in the Department of Animal and Wildlife Sciences are almost ready to be filled with exceptional candidates.

Agrometeorologist with his feet on the ground
Phumudzo Tharaga holds an MSc from the UFS, and is currently pursuing a PhD. Tharaga’s research focuses on quantifying the water use efficiency of sweet cherry orchards under different climate conditions in the Eastern Free State. Tharaga will offer his students a wealth of practical experience, which he began accumulating while working at ABSA as an agro-meteorologist, before moving on to become a senior scientist at the South African Weather Service. In 2015, Tharaga became a research technologist at the Council for Scientific and Industrial Research (CSIR) and then returned to the UFS as an nGAP candidate at the beginning of 2016.  

Description: Beynon Abrahams, nGap lecturer  Tags: Beynon Abrahams, nGap lecturer

Beynon Abrahams, nGap lecturer
at the Faculty of Heath Sciences
Department of Basic medicine

Motivated scholar turned academic
Neo Mathinya, who hails from Taung in the North West, has made the UFS her home. She received both her undergraduate and honours degrees from the university. Apart from joining the department as a lecturer under the nGAP initiative, she is currently studying for her MSc in Soil Physics. She will continue with this research when she comes to her PhD. Mathinya’s research focuses on soil salinity - the process of increasing salt content - which affects the ability of plants to take up water, a process, known as osmotic stress. She will investigate the effects of irrigation water salinity on the grain yield and quality of malt barley.

Researcher with a passion for crime prevention
Kelebogile Boleu joined the Department of Criminology in the Faculty of Humanities, with a fresh take on diversion and crime prevention. Boleu holds a BA Criminology (Hons) and is now pursuing her Master’s degree. She worked for NICRO a non-profit organisation specialising in social crime prevention and offender reintegration, with programmes that prevent young and first-time offenders from re-offending, thus reducing crime. Boleu said that her practical experience makes her lectures to third-year criminology students exciting. Boleu’s research focuses on analysing the value of pre-sentencing reports in assisting adjudicators to make well-balanced judgments in cases.   

Research with a winning plan for fight against breast cancer
Beynon Abrahams joined the Department of Basic Medical Sciences in the Faculty of Health Sciences. Abrahams holds a BSc, BSc (Hons), and MSc in Medical Biosciences from the University of the Western Cape. Abrahams’ Master’s research focused on breast cancer, research on which he is building in his PhD. This doctoral research involves the exploration of P-glycoprotein, a protein expressed on cancer cell and responsible for multi-drug resistance in cancer treatment. The aim of this research is to develop a therapeutic drug treatment strategy that will improve breast cancer patient survival outcomes. Abrahams’s greater vision is to look at conventional cancer therapeutic regimens, to find ways in which they can be improved.

The nGAP initiative offers these young lecturers an opportunity for growth and development as academics, while providing them with opportunities they would have not have been exposed to otherwise.

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