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25 July 2019 | Story Leonie Bolleurs | Photo Leonie Bolleurs
Plant Sciences Congress
At a public seminar, Understanding human evolution through the study of past environments in the Free State, presented by the UFS Department of Plant Sciences, were, from the left, front: Kristen Wroth, Britt Bousman; back: Prof Louis Scott, mentor in the UFS Department of Plant Sciences, and Michael Toffolo.

Florisbad, a thermal spring situated 45 km northwest of Bloemfontein on the edge of a large dry saltpan, is a well-known fossil site that used to be a large lake where giant buffalo, blue wildebeest, and hippos roamed thousands of years ago. Today, this fossil-bearing spring is not only a tourist attraction and a venue for weddings, but also an established quaternary research station that has attracted several palaeo-scientists since the 1930s, following the discovery of a remarkable human cranium and other fauna. 

Studies of past environments 

Three international researchers studying different aspects of archaeology at this and other sites in the Free State, recently presented lectures at the UFS to a multidisciplinary group of academics in plant sciences, geology, geography, and environmental management.

These lectures are part of the ongoing collaboration regarding fossil plant (pollen), fauna, and archaeological studies between the University of the Free State (UFS), the National Museum, and universities abroad.

Florisbad, a key site for understanding the appearance of modern environments as well as modern humans in Southern Africa, is the focus of the investigations of all three visiting scientists, aiming to provide a better understanding of past Free State environments where human evolution has taken place.

Michael Toffolo, a junior research chair from the University of Bordeaux Montaigne in France, focuses on the reconstruction of site-formation processes, palaeo-environments, and ancient human activities based on the study of the micro-morphology of archaeological deposits. He has been working in Southern Africa since 2013. The title of his lecture was: Reconstructing Pleistocene environments in the Free State by looking at the microscopic sedimentary record. 

Fluoride-preserved bones

Florisbad is widely known for the discovery of an archaic modern human skull of c. 260 000 years old. According to Toffolo, the human probably died, and the remains was left at the spring by the hyenas. The bones consequently absorbed fluoride from the spring water, which counteracted decomposition and helped to preserve it. 

Britt Bousman talked about middle and late Pleistocene terraces and archaeology in the Modder River Valley. He has worked in Southern Africa for the past 43 years and started his collaboration with researchers from the UFS and the National Museum in 1985. They have worked together at several sites, investigating palaeo-environments. Bousman teaches Archaeology in the Department of Anthropology at the Texas State University. 

While most scientists study early human records in rock shelters, especially those near the coast where seafood was harvested by prehistoric people, he is one of only a few researchers who studies the evolution of early human behaviour in central South Africa in the context of their activities in the open environment. 

“Rock shelters are good spaces for human behaviour,” says Bousman. He believes, however, that the Modder River area is a better space to study how humans have survived on the land under changing climatic conditions in the long term; for example, how they hunted and slaughtered animals. This can be seen from the many artefacts they left, such as spearheads, scrapers, etc. Interesting animal remains were also found, such as the bones of an extinct giant zebra at the Erfkroon site along the Modder River, with a head measuring 63 cm compared to that of a current zebra, which measures 54 cm. The only complete horn core of an extinct giant wildebeest was also found at the site. 

The first chemists

According to Bousman, technology changed in the Stone Age and included the production of more grinding stones, indicating that humans collected plants and grinded them. Observations of modern plant-collecting activities suggested that not many plant foods needed grinding. Bousman proposes that different plant components may have been grinded for medicinal mixtures, therefore these ancestors may have assumed the role of chemists. 

Kristen Wroth, a postdoctoral researcher in the Geoarchaeology Working Group at the University of Tübingen, Germany, presented a lecture on early human-environment interactions and ancient pyro technology. She uses a suite of micro-archaeological techniques such as phytolith (microscopic plant silica) analysis, micromorphology, and FTIR to understand both human and Neanderthal behaviour and to reconstruct how local environments have changed in space and through time.


News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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