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20 July 2020 | Story Leonie Bolleurs | Photo Supplied
The view from one of the offices in the Marion Island research station, with fresh snowfall in the interior of the island in the background.

Liezel Rudolph, lecturer and researcher in the Department of Geography at the University of the Free State (UFS), is strongly convinced that the Southern Hemisphere’s past glacial cycles will provide valuable insights to help predict and prepare for future climate change. Climate is changing fast and the magnitude of change we have seen over the last 30 years has taken a hundred or several hundred years to occur in the past. 

It is not only temperatures that are rising, but changes in wind patterns, rain cycles, oceanic circulation, etc., are also observed. As we do not know how the earth will respond or adapt to such rapid and drastic changes in climatic patterns, this poses various threats.

Link between landscape responses and climate change

Rudolph focuses her research on reconstructing the past climate of Marion Island. 

She had the wonderful opportunity to visit the island for the past three years with study and project leaders, Profs Werner Nel from the University of Fort Hare and David Hedding from UNISA, she departed on a ship to Marion Island to conduct fieldwork.They published their research findings of fieldwork conducted in 2017 and 2018.  

According to Rudolph, research in Antarctica, the Southern Ocean, and islands such as Marion Island is very important. South Africa is the only African country with research stations that have the ability to explore these regions.

“Marion Island has many landforms that could only have been created by glacial erosional or depositional processes, with glaciers currently absent from the island. To determine when the island was last in a full glacial period, we date the formation ages of these landforms.”

“In the short time we have been visiting the island, it was impossible to notice any drastic changes in the island climate. That is why we use these very old landforms to tell us more about periods before humans visited the island,” she says. 

Rudolph believes that understanding the link between landscape responses and climate change of the past can help to better predict some of the climate change processes that are currently threatening the planet.

“There’s a principle in geography called ‘uniformitarianism’, whereby we assume that the earth-surface processes we observe today, are the same as those that have been active in the past,” says Rudolph.

As scientists, they thus look at evidence of past geomorphic processes (which remain in the landscape in various forms, e.g. residual landforms, stratigraphic sequences, etc.) to piece together what the past climate was like. In the same way, they also use this principle to predict how certain earth processes will change in the future, along with climate changes.

“In return, we understand how the climate and the earth’s surface interact, and we can better predict how the earth will respond to climate change,” Rudolph adds. 

Society to play its part in climate change

In the long run, we as the public should play our part in readying society for the effects of climate change. 

Rudolph says society can play a positive role in terms of climate change by educating themselves with unbiased, scientifically sound information on the true state of climate change and by responding within their own spheres of influence.

“Don’t leave everything up to politicians and policy. As the public, you can start to make progress by assessing the effects that climate change may have on your industry, business or society, and strategise on how to adapt your processes to deal with these changes.”

“Be responsible with our natural resources, reduce your waste, support local businesses that are sustainable, and volunteer at a local environmental protection/clean-up organisation. All the small efforts will eventually add up to substantial change,” she says. 

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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