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26 April 2018 Photo Supplied
Pretzel-formed fossil of great evolutionary interest
Slab with holotype of Parapsammichnites pretzelifornic from the Urusis Formation, Namibia. Scale bar is 1cm.Picture was taken from Buatois et al., 2018.

The acclaimed scientific journal, Nature, recently published an article about a trace fossil in approximately 543-million-year-old rocks, which elucidates the evolution of the first animals that appeared on Earth and lived in the sea.  

Affiliated Professor in the Department of Geology at the University of the Free State (UFS) Prof Gerard Germs formed part of a team that conducted research with the aim of understanding how the evolution of the first multicellular animals came about and how the Cambrian explosion took place. Prof Germs is of great value to the team for his extended field geological knowledge.

An article which he co-authored was published in the Nature Scientific Reports. The title of the article is: “Sediment disturbance by Ediacaran bulldozers and the roots of the Cambrian explosion”. The international group of writers included authors from Canada, Spain and South Africa. 

Occurrence of the Cambrian explosion
Prof Germs explains the Cambrian explosion: “During the long (4.5-billion-year) history of the Earth, the first life originated and subsequently evolution of plants and animals took place from one-cellular organisms to multicellular vertebrate animals and seed plants. Approximately 573 million years ago the first multicellular animals appeared on the scene. Sometime afterwards, approximately 540 million years ago, a kind of explosion in the origin of many new animal species occurred. This explosion is known as the Cambrian explosion.”

The team studied Earth sediments which are somewhat older than the Cambrian explosion. Such sediments are approximately 573 to 541 million years old and form part of the Ediacaran (late Neoproterozoic) period.

“My discoveries of the past, of among others, the oldest animal with a carbonate skeleton (Cloudina) and of complex horizontal Cambrian-type “worm” tracks (treptichnids) in Ediacaran sediments of Namibia have demonstrated that the Cambrian explosion occurred more gradually than previously thought. This has recently been confirmed in the article that was published in the Nature Scientific Reports.”

Pretzeliformis bulldoze to search for food
According to the article there is evidence that   during the Ediacaran period   worm-like animals such as the Parasammichnites pretzeliformis were already so far developed that they, due to coelom development and size increase, for the first time in the history of the Earth, were able to disturb and bulldoze sediments.  In this way they were able to find a new food source in sea sediments. Bulldozing animals were previously thought to have originated only during and after the Cambrian explosion and not during the older Ediacaran.

“Another major aim of my cooperative research is to improve our knowledge of the geology of the Ediacaran to early Cambrian of South Africa and Namibia. We also intend to establish how the assembly of the supercontinent Gondwana took place. This improved knowledge can be of great future economic interest since large oil, gas and limestone sources occur in Ediacaran-age sediments outside South Africa”.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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