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26 April 2018 Photo Supplied
Pretzel-formed fossil of great evolutionary interest
Slab with holotype of Parapsammichnites pretzelifornic from the Urusis Formation, Namibia. Scale bar is 1cm.Picture was taken from Buatois et al., 2018.

The acclaimed scientific journal, Nature, recently published an article about a trace fossil in approximately 543-million-year-old rocks, which elucidates the evolution of the first animals that appeared on Earth and lived in the sea.  

Affiliated Professor in the Department of Geology at the University of the Free State (UFS) Prof Gerard Germs formed part of a team that conducted research with the aim of understanding how the evolution of the first multicellular animals came about and how the Cambrian explosion took place. Prof Germs is of great value to the team for his extended field geological knowledge.

An article which he co-authored was published in the Nature Scientific Reports. The title of the article is: “Sediment disturbance by Ediacaran bulldozers and the roots of the Cambrian explosion”. The international group of writers included authors from Canada, Spain and South Africa. 

Occurrence of the Cambrian explosion
Prof Germs explains the Cambrian explosion: “During the long (4.5-billion-year) history of the Earth, the first life originated and subsequently evolution of plants and animals took place from one-cellular organisms to multicellular vertebrate animals and seed plants. Approximately 573 million years ago the first multicellular animals appeared on the scene. Sometime afterwards, approximately 540 million years ago, a kind of explosion in the origin of many new animal species occurred. This explosion is known as the Cambrian explosion.”

The team studied Earth sediments which are somewhat older than the Cambrian explosion. Such sediments are approximately 573 to 541 million years old and form part of the Ediacaran (late Neoproterozoic) period.

“My discoveries of the past, of among others, the oldest animal with a carbonate skeleton (Cloudina) and of complex horizontal Cambrian-type “worm” tracks (treptichnids) in Ediacaran sediments of Namibia have demonstrated that the Cambrian explosion occurred more gradually than previously thought. This has recently been confirmed in the article that was published in the Nature Scientific Reports.”

Pretzeliformis bulldoze to search for food
According to the article there is evidence that   during the Ediacaran period   worm-like animals such as the Parasammichnites pretzeliformis were already so far developed that they, due to coelom development and size increase, for the first time in the history of the Earth, were able to disturb and bulldoze sediments.  In this way they were able to find a new food source in sea sediments. Bulldozing animals were previously thought to have originated only during and after the Cambrian explosion and not during the older Ediacaran.

“Another major aim of my cooperative research is to improve our knowledge of the geology of the Ediacaran to early Cambrian of South Africa and Namibia. We also intend to establish how the assembly of the supercontinent Gondwana took place. This improved knowledge can be of great future economic interest since large oil, gas and limestone sources occur in Ediacaran-age sediments outside South Africa”.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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