Latest News Archive

Please select Category, Year, and then Month to display items
Categories
UFS News Media Release Research
Years
2017 2018 2019 2020 2021 2022 2023 2024
Months
January February March April May June July August September October November December
Previous Archive
06 April 2018 Photo Rulanzen Martin
Researchers to represent UFS at BRICS Summit
From the left: Dr Thulisile Mphambukeli, leader of the BRICS research team that is exploring the political economy of water and food security, and her research partner, Dr Victor Okorie.

A Brazil, Russia, India, China and South Africa (BRICS) delegation is to hold the 10th Annual BRICS Summit in the last week of May 2018 in Johannesburg. Dr Thulisile Mphambukeli, leader of the University of the Free State (UFS) research team alongside Dr Victor Okorie from the Department of Urban and Regional Planning, in collaboration with Prof Lere Amusan of North-West University, will ensure that water and food security is a prominent feature on the gathering’s agenda.
 
First, the project titled: “Exploring the political economy of water and food security nexus in BRICS and Africa” will debut at the National Institute for the Humanities and Social Sciences BRICS Think Tank Forum”.

According to Dr Mphambukeli, the key to water security is attitudinal change by means of education and conscientisation. This, she is adamant about, holds the potential to drive behavioural adjustments in the way society interacts with water.
 
Genetic and social approaches
Dr Okorie asserts that if strides towards reducing the demand for water were to be made, research efforts should be geared towards effecting changes at DNA level. Meaning we need to explore waterwise ways that enable crops and animals to thrive optimally. 

The project also looks at social dimensions of water such as flushing a toilet. “Research activities on redesigning toilets, especially the urinal, where more than nine litres of water are used to flush less than one cubic centimetre of urine, are timely in the context of managing water and the food nexus crises,” said Dr Okorie.

Combining the genetic and social approaches would allow us to produce more with a smaller water footprint. This can be made possible by implementing precision agriculture which is about estimating and applying exact quantities of water and nutrients needed for the production of crops or the raising of livestock.

Paradigm shifting policies
Prof Amusan said the team intended to propose functional solutions that take the quality of water into consideration. Equitable production and distribution of water depends on endorsing policies of co-production between citizens, governments and the public sector. BRICS member states mutually consider water and food security as an issue of paramount significance, hence its feature on this prestigious summit’s agenda.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept