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06 April 2018 Photo Rulanzen Martin
Researchers to represent UFS at BRICS Summit
From the left: Dr Thulisile Mphambukeli, leader of the BRICS research team that is exploring the political economy of water and food security, and her research partner, Dr Victor Okorie.

A Brazil, Russia, India, China and South Africa (BRICS) delegation is to hold the 10th Annual BRICS Summit in the last week of May 2018 in Johannesburg. Dr Thulisile Mphambukeli, leader of the University of the Free State (UFS) research team alongside Dr Victor Okorie from the Department of Urban and Regional Planning, in collaboration with Prof Lere Amusan of North-West University, will ensure that water and food security is a prominent feature on the gathering’s agenda.
 
First, the project titled: “Exploring the political economy of water and food security nexus in BRICS and Africa” will debut at the National Institute for the Humanities and Social Sciences BRICS Think Tank Forum”.

According to Dr Mphambukeli, the key to water security is attitudinal change by means of education and conscientisation. This, she is adamant about, holds the potential to drive behavioural adjustments in the way society interacts with water.
 
Genetic and social approaches
Dr Okorie asserts that if strides towards reducing the demand for water were to be made, research efforts should be geared towards effecting changes at DNA level. Meaning we need to explore waterwise ways that enable crops and animals to thrive optimally. 

The project also looks at social dimensions of water such as flushing a toilet. “Research activities on redesigning toilets, especially the urinal, where more than nine litres of water are used to flush less than one cubic centimetre of urine, are timely in the context of managing water and the food nexus crises,” said Dr Okorie.

Combining the genetic and social approaches would allow us to produce more with a smaller water footprint. This can be made possible by implementing precision agriculture which is about estimating and applying exact quantities of water and nutrients needed for the production of crops or the raising of livestock.

Paradigm shifting policies
Prof Amusan said the team intended to propose functional solutions that take the quality of water into consideration. Equitable production and distribution of water depends on endorsing policies of co-production between citizens, governments and the public sector. BRICS member states mutually consider water and food security as an issue of paramount significance, hence its feature on this prestigious summit’s agenda.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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