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11 April 2018 Photo Oteng Mpete
UFS medical students improve life for kids at Lethabo Daycare Centre
UFS medical students donate furniture for the Lethabo Daycare Centre at the UFS Bloemfontein Campus. From left front are: Anda Gxolo, Tshepo Ntoule, the daycare centre principal Selina Keta, Andrea Bailey and Yenziwe Mbambo. Back from left: Ilyas Moola Malibongwe Jiyane, and Yusuf Moola Umar Kajee

There is strong evidence to suggest that improving a caregiver’s knowledge has an impact on a child’s development. This is according to the Human Sciences Research Council. With this in mind, medical students from the University of the Free State (UFS) decided to work with a children’s daycare centre in order to improve the quality of care.

The students, from the School of Clinical Medicine in the Faculty of Health Sciences, were encouraged to assist NGOs in and around Bloemfontein, as part of their community service curriculum. They needed to look at hygiene, sanitation, cognitive development, physical development, vaccinations, prevention of diseases, nutritional status, socio-economic status, as well as the children’s environment. Moreover, they needed to highlight how a deficit from one factor could affect the other factors.
 
Through a meta-analysis study of 67 interventions regarding the above points, the students found most interventions to be generally effective in improving the children’s lives in one way or the other.
 
Selina Keta, the principal of Lethabo Daycare Centre in Mangaung, provided a list of problems she faced and ways in which the students could help to improve the conditions at the centre. She noted that the kitchen needed fixing because it did not meet the specifications required by the Department of Education for registration. The main issue was that the gas bottle for the stove was inside the kitchen and had to be moved out. The kitchen also needed steel counters, a sink, and running water. The students moved the gas bottle outside, and provided a fire extinguisher and first aid kit. They also provided a teacher at the centre with first-aid training from St John in Bloemfontein.

The students made sure there was running water and donated cupboards and microwaves to the centre. They also helped build two new classrooms, and there are plans for a third one to cater for different age groups.
As a final gift, the students painted the playground walls and arranged for the teachers to attend skills development workshops. They are also building a toy library for the centre.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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