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UFS medical students improve life for kids at Lethabo Daycare Centre
UFS medical students donate furniture for the Lethabo Daycare Centre at the UFS Bloemfontein Campus. From left front are: Anda Gxolo, Tshepo Ntoule, the daycare centre principal Selina Keta, Andrea Bailey and Yenziwe Mbambo. Back from left: Ilyas Moola Malibongwe Jiyane, and Yusuf Moola Umar Kajee

There is strong evidence to suggest that improving a caregiver’s knowledge has an impact on a child’s development. This is according to the Human Sciences Research Council. With this in mind, medical students from the University of the Free State (UFS) decided to work with a children’s daycare centre in order to improve the quality of care.

The students, from the School of Clinical Medicine in the Faculty of Health Sciences, were encouraged to assist NGOs in and around Bloemfontein, as part of their community service curriculum. They needed to look at hygiene, sanitation, cognitive development, physical development, vaccinations, prevention of diseases, nutritional status, socio-economic status, as well as the children’s environment. Moreover, they needed to highlight how a deficit from one factor could affect the other factors.
 
Through a meta-analysis study of 67 interventions regarding the above points, the students found most interventions to be generally effective in improving the children’s lives in one way or the other.
 
Selina Keta, the principal of Lethabo Daycare Centre in Mangaung, provided a list of problems she faced and ways in which the students could help to improve the conditions at the centre. She noted that the kitchen needed fixing because it did not meet the specifications required by the Department of Education for registration. The main issue was that the gas bottle for the stove was inside the kitchen and had to be moved out. The kitchen also needed steel counters, a sink, and running water. The students moved the gas bottle outside, and provided a fire extinguisher and first aid kit. They also provided a teacher at the centre with first-aid training from St John in Bloemfontein.

The students made sure there was running water and donated cupboards and microwaves to the centre. They also helped build two new classrooms, and there are plans for a third one to cater for different age groups.
As a final gift, the students painted the playground walls and arranged for the teachers to attend skills development workshops. They are also building a toy library for the centre.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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