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13 August 2018 Photo Charl Devenish
Mountain research Maloti-Drakensberg
Tucked in the foothills of the Maloti-Drakensberg Mountains is the Qwaqwa Campus of the University of the Free State (UFS), the home of the Afromontane Research Unit (ARU).

Mountains and highlands have always played an important role in the history of mankind. They produce economically essential goods and services (such as fresh water), host unique biodiversity, and offer unique recreational and tourism opportunities. Mountains are also a place for spiritual sanctuaries and are often used for journeys of self-reflection through pilgrimage.

In addition to these ‘feel good’ benefits, mountains are hazardous areas for communities and infrastructure and are vulnerable to natural disasters. Mountainous areas are also often natural borders defining geopolitical entities, but in the process splitting and marginalising communities, creating economic shadow zones and sometimes becoming highly militarised areas. 

“Southern African mountains provide enormous opportunities for holistic research as social-ecological systems, with some of the most interesting and least academically explored environments on Earth,” said Dr Vincent Clark, Director: Afromontane Research Unit (ARU) on the UFS Qwaqwa Campus

The Afromontane Research Unit
The Qwaqwa Campus of the University of the Free State (UFS) is the home of the ARU, a multidisciplinary flagship group addressing the largely under-researched mountainous landscapes of southern Africa. 

Research in the ARU is promoted around three broad themes to foster inter- and multidisciplinary discourse: (1) conservation and sustainable use of Afromontane biodiversity; (2) sustainable futures for the people of the Afromontane; and (3) living and doing business in the Afromontane –  with the intention of creating a sustainability science hub to bring the three themes into the ambit of solution-oriented transdisciplinary research, centred in the sustainable development goals and sustainability research in general. 

Continental leader
To achieve its vision of becoming a continental leader in African mountain research, the ARU is positioning itself as a mountain-knowledge generator and interchange by developing key relationships locally and internationally. The most valuable local partnership is with the South African Environmental Observation Network (SAEON), with which the ARU will be sharing a Research Chair. 

The Chair will contain strong expertise in the Social Sciences to complement the existing strong Natural Science element in both the ARU and SAEON. The Sustainability Science component is being built through inter alia a mutually-reinforcing relationship with the University of Tokyo and United Nations University, Tokyo. 

The future
“In tandem with robust collaborations to achieve its goals, the ARU provides an envious capacity-building programme for its early career campus academics, postdoctoral and postgraduate students,” said Dr Clark. 

The scale of influence of the ARU is prioritised as ‘back yard first’, namely solution-oriented research that benefits Phuthaditjhaba, Qwaqwa, Golden Gate Highlands National Park and Royal Natal National Park. Thereafter, the ARU seeks to facilitate research that encourages the sustainable development of the Maloti-Drakensberg as a unique social-ecological system in Africa, and from there facilitate research in the intellectual vacuum that is the southern African mountains. With time, the ARU aims to take the intellectual lead as an Africa-based leader in African mountain research. The success of this will depend on how carefully the development of human infrastructure can be balanced with that of the myriad opportunities presented.”

With a diverse and motivated team, situated in one of the most attractive environments in Africa, the ARU is here to change the way we think about African mountains and what they mean for us all. 

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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