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29 August 2018 Photo Barend Nagel
Think three minutes is a long time
One slide and three minutes was all they had to present their research. Winners of the UFS Three-Minute Thesis competition in the Master’s category are from left: Nigel Masalla, Phuthi Samuel Masingi and Vuyisa Sigwela. Home page photo: Winners in the PhD Category were Trudie Strauss and Nokuthula Tlalajoe.

It may take three minutes to make noodles, but imagine presenting the 80 000-word research you spent months writing in just three minutes.

For master’s and PhD students participating in the annual institutional Three-Minute Thesis (3MT) competition at the University of the Free State (UFS), three minutes seem to go as fast as three seconds. Each participant is given three minutes to present the essence of their research, explaining the problem, methodology used, as well as the importance of their research using one slide.

A jubilant audience of staff members and students gathered at the Equitas Auditorium on the Bloemfontein Campus for the annual institutional 3MT competition. Interesting research topics across different fields of study, which the participants had spent months and even years researching, were presented in the master’s and PhD categories. After each presentation, a panel of judges and the audience had the chance to ask the participants questions on their research.

The competition is part of the initiative by the UFS Postgraduate School to showcase postgraduate research across disciplines, faculties, and universities. Participation in this competition helps to develop academic, presentation, and research communication skills to ensure that research students can effectively communicate their research in a language that even non-specialists can understand. 

It is the mandate of the school to “create an enabling environment for postgraduate students to excel in their pursuit of their academic quests”, according to Prof Witness Mudzi: Director of the UFS Postgraduate School. 

Winners at the event:

PhDs
• Third prize: Trudie Strauss - Babelish Confusion: Finding Statistical Structure in the Diversity of Languages (R3 000 cash prize)
• People’s choice: Nokuthula Tlalajoe - The transition of undergraduate first-year students into the MBChB programme: Social learning and integration

Master’s
• First prize: Phuthi Samuel Masingi   Physical demands of South African Football (R6 000 cash prize)
• Second prize and people’s choice: Nigel Masalla   “ Stealthing” – lifting the veil on non-consensual condom removal (R4 000 cash prize)
• Third prize: Vuyisa Sigwela - Extraction, characterisation and application of betalains from beetroot, cactus pear and amaranth (R2 000 cash prize)

The UFS will be represented by Trudie Strauss at the national 3MT competition on 26 October 2018. The national competition will take place on the UFS Bloemfontein Campus

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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