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06 December 2018 | Story Leonie Bolleurs | Photo Barend Nagel
Marcelle Vermeulen
Marcele Vermeulen, a graduate from the Department of Plant Sciences, explores possible threats to crop production; contributing to food security in South Africa.
Global food security is currently threatened both by climate change and the low diversity of crops relied on by humankind to feed a growing world population. Marcele Vermeulen, a graduate in the Department of Plant Sciences who will receive her PhD at the December graduation ceremonies at the University of the Free State (UFS), is part of a team that is working hard to add to the diversity of staple foods in South Africa.

In the drive to focus on alternative crops, Marcele is researching the crop, Amaranthus cruentus, (grain amaranth). It is more tolerant to environmental stress for large-scale production, thereby also diversifying staple crops.

Relatively new development

“Amaranthus cruentus is an excellent candidate due to its high nutritional value and tolerance to drought and high temperatures. It can be mixed with conventional maize meal, to increase the protein intake of its consumers,” said Marcele.

The production of A. cruentus as a grain crop in South Africa is a relatively new development.

In her research, exploring the possible threats to crop production and paying particular attention to dominant plant pathogens in the Amaranthus cruentus, Marcele found a correlation between fungal pathogens and insect pests. 

Insect pests can influence plant diseases

Although reports on fungal pathogens and pests specific to A. cruentus are limited to and information for South Africa is limited to this study, there is a possibility that by controlling insect pests such as weevils, one might also be able to control fungal pathogens of Amaranthus cruentus.

Marcele believes that control of weevil pests should thus be the focus of future pest and pathogen management strategies and breeding programmes in A. cruentus.  

“Knowledge gained in my thesis will hopefully aid in the development of future cultivation practices, integrated pest/pathogen management programmes, as well as for the registration of crop protection products for A. cruentus,” Marcele added.

Research Contributes to Food Security from University of the Free State on Vimeo.

News Archive

Collaboration between UFS and Mayo Clinic to revolutionise cancer treatment
2014-06-27



Attending the lecture were, from the left: Dr Chantel Swart, Prof Lodewyk Kock, Prof Debabrata Mukhopadhyay, Prof James du Preez; back: Prof Pieter van Wyk. Dr Swart, Profs Kock and Du Preez are from the Department of Microbial, Biochemical and Food Biotechnology. Prof Mukhopadhyay is from the Mayo Clinic (US) and Prof Van Wyk is from the Centre for Microscopy at the UFS.
Photo: Supplied
The UFS made a discovery that may have enormous implications for the treatment of diseases in humans.

Since the discovery, the UFS joined forces with the Mayo Clinic in Rochester, US, in the fight against cancer.

In this collective effort, UFS researchers would be able to assist the Mayo team to:
• see how treatment in cancer patients is progressing,
• target treatments more effectively,
• reduce dosages in order to make treatment gentler on the patient,
• track the effectiveness of the chemotherapy drugs used, and
• gain an accurate view of how the cancer is being eliminated.

Prof Lodewyk Kock, Outstanding Professor at the Department of Microbial, Biochemical and Food Biotechnology, and his team incidentally created a technique to use argon gas particles for the first time on biological material to slice open cells to look inside.

The team that supported Prof Kock includes Dr Chantel Swart, Khumisho Dithebe (PhD student), Prof Hendrik Swart (Department of Physics) and Prof Pieter van Wyk (Centre for Microscopy).

Prof Debabrata Mukhopadhyay from the Mayo Clinic in Rochester, US, got to hear about this breakthrough at the UFS and a collaboration between the two institutions was established.

During a visit to the Bloemfontein Campus, Prof Mukhopadhyay explained novel techniques that make use of gold nanoparticles. These particles attach to chemotherapeutic drugs to selectively target cancer cells – dramatically decreasing the side effects to normal human cells.

For these new drugs (coupled to gold nanoparticles) to be accepted into clinical practice, visual and chemical proof is needed, though. This is where the technique developed by the UFS will play a vital role.

With the technique to look inside cells, the composition, location and metabolism of these drugs can be determined. This will aid in a proof of concept for the application of the nano-drugs. Furthermore, it will enable approval for use of these drugs in clinical trials and eventually could revolutionise cancer treatment as a whole.

For video lectures on the technique used, as well as its findings, follow these links:

1. http://vimeo.com/63643628 (Comic version for school kids)

2. http://vimeo.com/61521401 (Detailed version for fellow scientists)

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