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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.

South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

Nominations for Kovsie Alumni Awards now open
2008-10-24

It is time once again to nominate candidates for the University of the Free State’s (UFS) three Kovsie Alumni Awards made annually.

Nominations can be made for the Kovsie Alumnus of the Year Award, Cum Laude Award and the Alumni Award for Exceptional Service to the UFS. The Kovsie Alumnus of the Year Award honors the outstanding achievements of a Kovsie Alumnus on national or international level. The person must still be in life. The Cum Laude Award is occasionally bestowed on an alumnus for outstanding service or achievement on regional, national or international level in his/her field of work. The Alumni Award for Outstanding Service to the UFS is occasionally made to any person (not necessarily an alumnus) who delivered exceptional service to the university.

Nominations should contain the following:

  • Any alumnus can submit a written nomination for the above-mentioned awards.
  • At least five alumni seconders must support the nomination.
  • A comprehensive motivation and a brief Curriculum Vita of the candidate must accompany the nomination.
  • The candidate’s complete address and telephone number must also be provided.

Nominations can be submitted to Ms Annanda Calitz or Mr Lucas Radebe, Alumni Awards, PO Box 2319, Bloemfontein, 9300. Nominations may also be faxed to 086 523 5108 of send via e-mail to ficka.stg@ufs.ac.za  or radebesl.stg@ufs.ac.za . The closing date for submission of nominations is 20 of November 2008.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
24 October 2008
 

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