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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.
South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

A real indaba it was
2010-09-07

Pictured from the left, are: Prof. Dennis Francis (Dean), Prof. Rita Niemann (Director: Postgraduate Studies and Research) and Prof. Rob Pattman (Keynote speaker: UKZN).

No expert panels! No rubrics! Only a fair measure of healthy anxiety that goes with public speaking!

These features describe the meeting that staff members from the Faculty of Education recently had at Indaba Lodge on the banks of the Modder River. The purpose of this get-together was to create a time and space where staff members could not only celebrate their own research efforts, but also acknowledge, support and validate one another’s work.

The day kicked off with the dean’s research vision for the faculty. Thereafter seven staff members doing their Ph.D.s were introduced. Their presentations were followed by inputs from the guest speaker, Prof. Rob Pattman from the University of KwaZulu-Natal (UKZN). He congratulated the presenters on their cutting-edge research, their eloquence and the manner in which they managed to communicate complex matters in simple ways. Ideas he shared from his own research on social identities and critical agency (with a focus on gender and race) served to affirm the relevance of the topics presented by the Ph.D. candidates in transforming the education system as well as the South African society as a whole.

A festive lunch, in honour of retiring Prof. Johan van Staden, brought an affective dimension to the Indaba in the form of heart-felt goodbye messages from colleagues who had shared his academic life for more than 20 years.

After lunch five master’s students had the opportunity to share their research in the form of poster presentations. A lively interest among participants and critical, but constructive questions characterised this session. A potpourri session followed, comprising work in progress, completed surveys, research awards and innovative research methods.

The wrap-up by Prof. Dennis in no uncertain terms affirmed that researchers in the Faculty of Education not only crossed the Modder River, but also the proverbial Rubicon on 21 August. It was envisaged that henceforth:
- Supervision will take on a collaborative character.
- Soon a research forum for Ph.D. students and their supervisors will be established where these students and supervisors can start practising their agency.
- Instead of relying on outside experts who come and “tell” faculty staff members what to do, insiders should start building their own vibrant research-based practices by forming reading groups to discuss seminal works (e.g. Foucault and Freire) and research methodologies (e.g. Burke’s Pentad).

The Indaba was aptly concluded by one of the participants who, on behalf of all attendees, thanked and congratulated the dean on the initiative to give impetus to research. Analogous to the 2010 slogan, Feel it, it is here!, he said: “I feel so inspired and empowered, I can almost taste it!”
 

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