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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.

South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

SA-YSSP strengthens academic partnerships between countries
2014-11-17

 

Deputy Minister of Science and Technology, Zanele Magwaza-Msibi
Photo: Stephen Collett

Students from all over the world and all walks of life have come together at the Bloemfontein Campus to take part in the Southern African Young Scientists Summer Programme (SA-YSSP) hosted by our university.

This prestigious academic programme is an annual three-month education, academic training and research capacity development programme. The programme is presented in collaboration with the International Institute for Applied Systems Analysis (IIASA) as well as the National Research Foundation.

Dr Priscilla Mensah, Director of the SA-YSSP, says this programme’s Doctoral candidates are given the opportunity to advance their research under the direct supervision of senior scientists from South Africa and IIASA.

“In line with international trends in doctoral education, the SA-YSSP seeks to advance not only the discipline-specific research skills of the young scientists, but also equip and expose scholars to an array of additional competencies and skills required to be successful in knowledge-driven societies,” Dr Mensah says.

During her keynote address, Deputy Minister of Science and Technology, Zanele Magwaza-Msibi, praised the UFS for hosting this successful programme for the third year. “The success of this programme shows in the increase in applicants internationally but specifically in our SADEC regions.”

She said that solutions to the problems in the world require a wide variety of knowledge and integrated approaches to the unique challenges in different countries.

Deputy Minister Magwaza-Msibi also regards the SA-YSSP as a very successful platform to strengthen partnerships with countries.

 

 

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