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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.
South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

First-years at South Campus step into a bright future
2015-02-05

Photo: Stefan Lotter

This is the first step to a bright future.

This was the resounding message that welcomed first-year students to the South Campus. “Remember,” Tshegofatso Setilo, Manager of the University Preparation Programme said, “a journey of a thousand miles begins with the first step.” But please do not get discouraged on your way, she urged, because “this is your first step to a bright future.

In his welcoming message, Prof Nicky Morgan, Vice-Rector: Operations at the UFS referred to the South Campus as the giant of the south. “This is one of the trailblazing campuses of the university,” he said. “No doubt what you’ll experience on this campus, you’ll never forget.”

This year, the South Campus boasts with 1 200 first-year students taking part in our University Preparation and Extended Programmes. These programmes allow students – whose matric marks did not reach the required total – the opportunity to study at the University of the Free State (UFS). The result? An astounding rise in pass rates. Some of the students on the South Campus outperform their peers studying at the Bloemfontein Campus, Prof Morgan remarked.

“You’ve got it in yourself. You’ve got the potential to unleash yourself on the world,” Prof Morgan said. You do not always realise the value of something that has come your way, he said. So, every moment you get an opportunity, he advised, use it to shape your future.

Addressing the newcomers’ fears, Prof Morgan urged each student to open themselves to the good and new experiences waiting for them. “When you find yourself in a new space, it always begins with you,” he said. Learn to understand how to live in harmony in different spaces.

Prof Morgan placed great emphasis on his closing remark: “At university, the more questions you seek to have answered – they’re worth more than the answers you have.”

 

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