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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.

South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

UFS adopts advanced institutional approach to disability, launches CUADS
2015-07-14

Lize Botha, Louzanne Coetzee and her guide-dog Oakley, and David Nkwenkwezi.

Photo: Eye Poetry Photograpy

The approach to support for students with disabilities at South African universities has remained largely one-dimensional, focusing on the support and accommodation of individual students. Implementing the Universal Access (UA) and Universal Design (UD) approach has aligned the University of the Free State (UFS) with international standards. Such an approach addresses challenges arising as a result of the interaction between functional limitations and the social, attitudinal and physical environment of students with disabilities. The Unit for Students with Disabilities (USD) has evolved into the Center for Universal Access and Disability Support (CUADS) in support of the social model of disability. 

Hetsie Veitch, Head of CUADS and her team, have dedicated the past four years to the center’s physical revamping and systematic reconstruction to be officially launched in an Open Day event on the Bloemfontein Campus.


Details of the event:

Date: Friday 24 July 2015
Time:10:00-16:00
Venue: CUADS and Sasol Library foyer
Members of the public are welcome to attend.

Exploring the dimensions of UA and UD


UA and UD facilitate holistic support for students with visual, mobility, hearing, learning, and other impairments. With the former providing a paradigm shift in disability management and support, the latter warrants the formation of a universally accessible environment.

According to Veitch, the focus moves away from the person with the disability, someone who ‘needs to be helped’, to the environment in which that person needs to function.

Since the center was founded in 2001, structural and systematic developments have occurred in order to create a welcoming and accessible learning environment that grants students opportunities to be successful in their academic endeavours.

UA endorses the UFS Mission Statement of human togetherness, advancing social justice by creating multiple opportunities for students to access the university, and promoting innovation, distinctiveness, and leadership in both academic and human pursuits.The UFS is committed to be a welcoming, accessible, and inclusive learning institution, an environment where optimal learning for a diverse student community thrives.

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