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03 December 2018 | Story Thabo Kessah | Photo Thabo Kessah
Dr Martin Mandew welcoming ceremony
Prof Francis Petersen, Dr Martin Mandew, UFS Council Chairperson Willem Louw, and Prof Prakash Naidoo, Vice-Rector: Operations.

The University of the Free State Qwaqwa Campus and the broader community gave the new Principal, Dr Martin Mandew, a warm welcome on Thursday 22 November 2018. In attendance were representatives from different stakeholders, ranging from the Thabo Mofutsanyana Education District, the UFS Council, to the Student Representative Council (SRC) who challenged Dr Mandew to take the campus to greater heights.

In welcoming Dr Mandew, the Rector and Vice-Chancellor, Prof Francis Petersen, highlighted recent campus achievements, including increased enrolment for both undergraduate and postgraduate students. “There has been a tremendous growth in our enrolment for both under- and postgraduate students. First-time undergraduate students grew by 124% from 2015 to 2018 – from 1 027 to 2 300 students. Regarding postgraduate students, we grew by 68% – from 329 to 551 in the same period of time. In addition, the University Staff Doctorate Project (USDP) that seeks to increase the number of academics with PhDs, is already unfolding. This programme will see six academics pursuing doctorate degrees in natural sciences, social sciences, the humanities, economic management sciences, and education, but will be focusing on multidisciplinary research on mountains or mountain communities. This Afromontane Research Unit (ARU) project is performed in collaboration with three American universities – the Appalachian State University, the Colorado State University, and the University of Montana,” he said.

“We have also seen increased research output that came partly as a result of our ARU collaborating with the United Nations University and the University of Tokyo’s Graduate School of Frontier Sciences in Japan. This partnership is aimed at developing the campus to be a sustainability hub of research and education, focusing on mountain and rural regions in South Africa,” he added.

Prof Petersen also acknowledged the role Dr Mandew was already playing in “broadening the reach of community engagement, integrating all efforts by different faculties and departments into one sustainable programme and integrating commuting or day students into university life”.

Speaking on behalf of the Qwaqwa Campus Branch of the National Education, Health and Allied Workers’ Union (NEHAWU), Deputy Chairperson, Motlogelwa Moema, highlighted the need for the new Campus Principal to always listen to the workers. “Workers themselves will tell you about their issues and you will not read about them in some minutes or written notes from somewhere,” he said. Representing UVPERSU was Grey Magaiza, who extended a hand of cooperation to Dr Mandew. “We are prepared to share your agenda of developing this campus with you, and you can count on us,” he said.

In his response, Dr Mandew also extended a hand of cooperation to those willing to see the campus becoming an institution of choice. “It has to be emphasised that this event is not about me, but about our biggest stakeholders – our students – and how we can advance our campus together and make it better. We must make this campus the best of its size in the whole of South Africa,” he said.

His Majesty Morena E Mohono Moremoholo Mopeli from the Bakoena Ba Mopeli Traditional Council welcomed Dr Mandew with a Basotho blanket, a rod, and a hat – symbols of the highest level and warmest welcome.


News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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