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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Lecture honours one of SA’s greatest women leaders
2008-08-22

A member of the national executive committee of the ANC Women’s League, Yolanda Botha, has called on all South Africans to cherish the legacy of Charlotte Maxeke, one of South Africa’s greatest women leaders.

Ms Botha was delivering the first Charlotte Maxeke Memorial Lecture at the University of the Free State (UFS) in Bloemfontein last night, in honour of the pioneering role played by Maxeke in the struggle for human rights, democracy and freedom. The lecture series is a partnership between the Free State Provincial Government and the university.

She was born Charlotte Makgomo Manye on 7 April 1874 at Ramokgopa in the Polokwane district in Limpopo. In 1905 she graduated from the Wilberforce University in Ohio in the USA with a B.Sc. degree, making her the first black South African woman to graduate with a science degree.

She married the Rev. MM Maxeke, a prominent AME minister who had also been educated overseas, and together they collaborated on the compilation and publication of the first AME church hymn book in Xhosa.

Later she became a founder member and president of the Bantu Women’s League, forerunner of the ANC Women’s League. She was an early opponent of the pass laws for black women and an organiser of the anti-pass movement in Bloemfontein.

Charlotte Maxeke died in 1939. Two years later, an ANC conference held in Bloemfontein, passed a “resolution on the women’s section”.

Elaborating on the challenges that women still face, Ms Botha said poverty remains a challenge affecting the majority of women. She called on all women to unite and engage with government to develop a comprehensive strategy for food security and agricultural support programmes to eradicate poverty.

Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za

22 August 2008

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