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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Children with diabetes learn from each other
2012-05-08

 

Young diabetes patients.
Photo: Supplied
8 May 2012


Children with diabetes often think they are the only ones who live with this condition. For this reason, the Department of Pediatrics and Child Health from the UFS, in cooperation with our Department of Nutrition and Dietetics, annually offers a camping weekend in Bloemfontein for young diabetic patients.

This fun-filled yet informative weekend was held at Emoya Estate in Bloemfontein recently. This is the fourth year that it has been held. During the weekend, the children learnt how to be a “child” along with other children.

“Children with diabetes have many emotional issues that they must work through,” says Dr Ute Hallbauer of the Department of Pediatrics and Child Health.

 “Diabetes is a daily challenge for these children. During the camp, we try to make the children feel special and teach them how to take care of themselves.”

Twenty-six children between the ages of 9 and 14, who receive treatment in the public and private sector, attended the camp this year.

Dr Hallbauer says children as young as 12 months and even younger can be diagnosed with diabetes.

“They usually have Type I diabetes. This autoimmune disease destroys insulin producing cells in the pancreas. Thus the young children are insulin dependent and they have to, depending on their treatment, inject themselves daily. They must also test their blood sugar levels daily.”
 

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