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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Seminar puts language issues under spotlight
2012-06-29

The South African Languages Bill does not meet the Constitution’s requirements and is not doing much to curb English monolingualism.

This viewpoint of a number of critics was discussed at a language seminar at the University of the Free State (UFS) this week.

The Faculty of the Humanities at the UFS presented the seminar on the Bloemfontein Campus, where interested parties could discuss issues and developments relating to the South African Languages Bill.

The seminar formed part of the combined annual conference of the South African Applied Linguistics Association, the Linguistic Society of Southern Africa and the South African Association for Language Teachers.

At the conference, the rich diversity of language and also the complexity of language in South Africa was recognised.

The latest South African Languages Bill has attracted much interest and varied viewpoints this past year.

One of the most significant - and also the most controversial - suggestion of the present bill is to extend the present bi-language obligation to a four-language obligation, which implies that at least one African language is added to the present formula.

Furthermore, there are other important stipulations regarding the establishment of language units that will have implications for the public service, and specifically, for language practitioners.

Prof. Koos Malan, a Constitutional Law expert from the University of Pretoria, speaking during a discussion session, said: “Language determination in constitutions and language legislation are indications of the official ideology towards dealing with language and cultural diversity in the specific state. The ideology can range from the support of multilingualism – at the one extreme – to the other extreme, where only one language will get preference as the official language.”

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