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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.
The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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News Archive

Two of our academics contribute to a fascinating book
2012-08-11

Prof. Jo van As earlier this year with proofs of the book The Story of Life & the Environment: An African Perspective.
Photo: Leatitia Pienaar
10 August 2012

The planet has more species than ever before, but humans are responsible for the biggest mass extinction of all times. This is according to Prof. Jo van As, Head of the Department of Zoology and Entomology. He was speaking at the launch of the book The Story of Life & the Environment: An African Perspective.

The book was published by Random House Struik in July 2012 and is a sister publication of The Story of Earth & Life by Prof. Bruce Rubidge, which was published in 2005.

The Story of Life & the Environment: An African Perspective took five years to complete. Prof. Van As was the compiling author, with Prof. Johann du Preez, Head of Plant Sciences at our university, Prof. Leslie Brown of Unisa and Prof. Nico Smit of the North-West University as co-writers.

Prof. Van As said, “No other species has destroyed the earth as we have done. Biological diversity disappears at the rate of mass extinction. The effects of human activities on the biological diversity is bigger that the extinction of the dinosaurs.”

He, however, added that The Story of Life & the Environment: An African Perspective does not sketch a doomsday scenario. It has also a message of hope. Prof. Van As said it was good to see progress in conservation and care for the environment. Trans-frontier parks the size of some countries are a good example of work in this regard.

Mr Stephen Johnson, chairperson of the board of Random House Struik, said at the launch that the publishing house was proud to be associated with the impressive book. The publication will be a touchstone for thoughtful readers for a long time. It will also remain a general book for the public and learners on the topic. The content and design was done in such a way that the publication will be relevant to all audiences.

The Afrikaans version of the book, Die Verhaal van Lewe en die Omgewing, will be published soon.
 

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