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Research possibilities of zebrafish exposed

24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Moeletsi Mbeki discusses South Africa’s political economy

2012-08-17

At the guest lecture was, from the left: Johann Rossouw, lecturer in the Department of Philosophy, Mr. Moeletsi Mbeki, and Prof. Pieter Duvenage, Head of the Department of Philosophy.
Photo: Johan Roux
17 August 2012

South Africa’s ongoing problems do not have their origin in the apartheid dispensation but in the British colonial period. This is according to the well known businessman and political analyst, Mr Moeletsi Mbeki, who was speaking during a guest lecture at the University of the Free State.

Mr Mbeki said the high unemployment rate among Blacks arose from the destruction of the Black small farming class in the last third of the 19th century to provide cheap labour to the developing mining sector. He said the notorious Land Act of 1913 was not the root of Black people’s loss of land but merely the legal formalisation thereof. Mr Mbeki emphasised that as long as it was argued that South Africa’s problems arose during the apartheid dispensation, problems would remain unsolved.

Regarding South Africa’s future, Mr Mbeki argued that three issues in particular were important – South Africa’s industrialisation, which ground to a halt in the 1970s, should be revived; the large scale training of industrialists with special emphasis on mathematics, science and the broader education system; and post-nationalist politics, of which parties such as Zimbabwe’s MDC, Zambia’s MMF and Mauritius’s MMM were outstanding examples.

The guest lecture was presented by the Department of Philosophy. More than 200 people attended the lecture and participated enthusiastically in the question and answer session. Afterwards, Mr Mbeki said he was impressed with the high level of the questions asked by students, which he said gave him hope for South Africa’s future.

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