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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Charlotte Maxeke Memorial Lecture launches national Women’s Month Celebrations
2012-08-17

Free State Premier Ace Magashule with President Jacob Zuma during the Charlotte Maxeke Memorial Lecture held on the Bloemfontein Campus.
Photo: Stephen Collett
6 August 2012

 

“Mother of African Freedom, heroine, teacher, unifier and true revolutionary.”

That is how dignitaries such as President Jacob Zuma, African Union (AU) Commission Chairperson Dr Nkosazana Dlamini Zuma, Basic Education Minister Angie Motshekga and others described Charlotte Maxeke, the woman they came to celebrate at the University of the Free State on 4 August 2012.

President Zuma honoured the life of the ANC Women’s League stalwart in delivering the fifth annual Charlotte Maxeke Memorial Lecture. The event officially kicked off the national Women’s Month celebrations and thousands of people made their way to the Bloemfontein Campus to listen to the President’s address.

President Zuma told the audience in the Callie Human Centre that women activism had not started with the 1956 march to the Union Buildings – it began much earlier. He spoke about Charlotte Maxeke’s leading role in the landmark 1913 march against pass laws in Bloemfontein and said this had inspired bravery and enthusiasm in the hearts of many in the struggle.

“As a collective, we must emulate the contribution of Mama Maxeke. In her honour, we must continue to open new paths for women, enable them to break new ground in leadership." President Zuma said Charlotte Maxeke, who believed a woman’s place was everywhere, had to be smiling with regard to Dr Dlamini Zuma’s appointment as Chairperson of the AU Commission.

In her speech, Dr Dlamini Zuma encouraged women to embrace the African Decade of Women, saying it was their responsibility to define and implement the changes they want to see. “We should define for ourselves what this decade means, define that we want to do, the role we want to play and achieve during this decade.”

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