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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Student organisation tackles difficult questions in debate
2012-05-12

 

At the debate were, from the left: Danie Jacobs, Head of the Centre for Business Dynamics, Mhlanganisi Madlongolwana, Nombuso Ndlovu and Prof. JP Landman.
Photo: Leatitia Pienaar

 

“South Africa is consumed by a monster, namely the lack of critical thinking and dialogue with regard to our problems. Now is the time to make radical changes.” This is according to Nombuso Ndlovu, who spoke at the first debate in a series of Commercio and the UFS Business School.

“Young people are more interested in social gatherings than applying their minds to the problems of South Africa,” she said. Nombuso is the CEO of Commercio.

Commercio is the student organisation in the Faculty of Economic and Management Sciences. Two teams, one positive and one negative, debated the topic: Is South Africa’s current economic direction viable?

What emerged from the debate was that our students are well-aware of what is going on in our economy and that people cannot just sit back and expect government to deliver. Every individual has a responsibility. South Africa has a “democratic deficit” society, a “corruption-stricken economy” and “economic activism” is necessary to get the economy on the right path.

Prof. JP Landman, Visiting Professor at the Business School, economic advisor, analyst, columnist and also managing director of the Aardklop Arts Festival, was the expert panel member. He said the critical issue in South Africa is “how do you distribute wealth while keeping things going?”

“It is fantastic that South Africans have developed a collective repulsiveness for corruption.” People must know what underpins society and where aggression comes from.
– Leatitia Pienaar.

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