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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Summer programme a first outside Austria
2012-12-06

 

Mr Derek Hanekom, Minister of Science and Technology
Foto: Johan Roux

05 Desember 2012

People often fight about their differences, like skin colour, religion and more. “These differences are minute. We must celebrate our common ancestry and commit ourselves to a common destiny. Your work can make a difference.” This is according to Mr Derek Hanekom, Minister of Science and Technology.

He opened the Southern African Young Scientists Summer Programme (SA-YSSP) at the Bloemfontein Campus on Sunday 2 December 2012. The UFS is the first institution outside Austria to host the Summer Programme. A total of 19 young researchers from 17 countries will be hosted by the UFS until 28 February 2013. Researchers in the programme are, among others, from South Africa, Egypt, China, Italy, Sweden, Iran, Hungary, India, the USA and Indonesia.

The programme will form part of an annual three-month education, academic training and research capacity-building programme jointly organised by the International Institute for Applied Systems Analysis (IIASA), based in Austria, the National Research Foundation (NRF) and the Department of Science and Technology (DST). IIASA is an international research organisation that conducts policy-oriented scientific research in the three global problem areas of energy and climate change, food and water and poverty and equity. South Africa’s engagements with IIASA, specifically with regard to the SA-YSSP, relate primarily to the DST’s Ten-Year Innovation Plan.

Mr Hanekom spoke about the impact the growing global population, which is expected to grow from 7 billion in 2012 to 9 billion in 2050, has on natural resources. “We use purified water to flush our toilets while other people do not have clean drinking water. We cannot carry on like this. Somewhere it must stop, if we do not want to be responsible for the 6th great extinction. We must know how our systems impact on each other.

“We can do things differently and better and should endeavour that other people enjoy luxuries we take for granted,” he said.

He urged the researchers to believe that they can make a difference, share knowledge and translate the knowledge into plans.

Prof. Dr Pavel Kabat, Director/CEO of IIASA, said the summer programme was presented outside Austria for the first time, with plans to expand to Brazil and China in future. Twenty countries are represented on the IIASA board, with more than 3 000 researchers associated with the organisation.

IIASA was launched in 1972 in the days of the Cold War as a “science bridge” between the West and the Soviet Union. It served as a “think tank” for various issues that needed to be resolved. Its mission was reconfirmed after the fall of the Berlin Wall in 1989.

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