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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

‘This university gives me hope’
2013-10-02

 
4 October 2013
Photo: Stephen Collett

“This is a university that gives me hope. It has a willingness and a capacity to care,” Brand Pretorius said at a farewell function at the UFS.

He served the university as honorary professor in the Department of Business Management since 1991 and delivered the Brand Pretorius lecture for the past two decades. His recent lecture dealt with the topic “Guidelines for sustainable personal success in business – lessons I learnt”.

He retired as CEO of McCarthy and as an executive director of the Bidvest Group on 1 March 2011. Currently he serves as a non-executive director on the boards of the Barclays Africa Group, Reunert, RGT Smart, Tata Africa Holdings and Tongaat Hulett. He is the non-executive chairman of Italtile Limited.

Pretorius said at the farewell function the UFS is still a source of inspiration and pride. The leadership has a lot of courage and commitment and embraced change. “They embraced the fact that we are living in a different world.

“The vision of the UFS is inspirational. It wants to be recognised for academic and research excellence. The university became a pioneer in reconciliation in a very difficult world. Change comes with pain, and the UFS dealt with it in a worthy manner.

“I am proud of this institution because it still strives for high standards, the right principles and values and it has respect for all people.”

Pretorius said the university’s heart is in the right place. “It is a beacon of hope of what the rainbow nation will be in South Africa one day. Reconciliation is a sign that this is happening.”

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