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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Stochastic Modelling for Reliability from Russia
2013-12-20

 

 Prof Maxim (MS) Finkelstein’s
The Russian professor first visited our university in 1993 and loved the environment. For the last 15 years we were fortunate to have had a man of Prof Maxim (MS) Finkelstein’s (65) stature as part of our Department of Mathematical Statistics.

“I like the atmosphere, the environment and the people of the UFS,” says Prof Finkelstein. “The UFS is a real campus, not part of the city as a lot of other universities in South Africa.”

Prof Finkelstein completed his MSc in Mathematical Physics from the Leningrad State University in the USSR in 1971. Maths and Physics have been a passion of his since a young age. In 1979, Prof Finkelstein completed his PhD in Mathematical Theory of Reliability at Leningrad Elektropribor Institute. Before his career at our university, Prof Finkelstein was a Senior Researcher at St. Petersburg Elektropribor Institute and an Associate Professor at Leningrad Technological Institute.

His long list of publications includes over 170 papers and five books. His monograph Failure Rate Modelling for Reliability and Risk was published by Springer in 2008. More recently another monograph – which was co-authored with JH Cha – was published by Springer in April 2013 and is called Stochastic Modelling for Reliability: Shocks, Burn-in, and Heterogeneous Populations.

Prof Finkelstein’s research interests include mathematical theory of reliability, survival analysis, risk and safety modelling, stochastic processes and stochastics in demography. When asked about leisure and life outside of research, the devoted academic’s response was as follows…

“To have publications, you have to work all the time. I work half of Saturdays and most of Sundays,” Prof Finkelstein says. “I spend three months a year in Russia and Germany – mostly during the European summer – for my research.”
“But apart from that, I like reading – classical Russian authors mostly. I swim in the UFS’s swimming pool almost every day and I play tennis as well.”

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