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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Workplace bullying can cause a toxic teaching environment
2014-04-15

A study done by the University of the Free State’s Faculty of Education exposed how teachers in South Africa fall victim to bullying in the workplace on a daily basis.

This study by Prof Corene de Wet from our School of Open Learning and Dr Lynette Jacobs from our School of Education Studies, exposed the commonness of workplace bullying (WPB) among teachers.

More than 2 700 teachers, from all school levels in urban, township, informal settlements, rural and farm schools, took part in a 43-question survey. Teachers from eight provinces were included in the study.

About 90% of the respondents were victims of WPB by school colleagues and/or management during the 12 months that preceded the study.

These acts included direct shunning, having untrue things said about them, verbal abuse, threats and ridicule, insults and teasing, damaging of possessions as well as physical violence.

Dr Jacobs says WPB is an extremely serious problem in some South African schools, compared to the occurrence in other countries.

“South African teachers are working in ‘toxic’ environments characterised by disgruntled, overworked and stressed teachers. There often are high levels of learner-on-learner and learner-on-educator violence and bullying, communities fraught with moral degradation, racial conflict, violence, lawlessness and economic despair. In schools where despair and disrespect prevail, teachers often turn on one another,” she says.

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