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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Music lecturer’s innovative app is a first in South Africa
2014-07-24

Dr Frelét de Villiers, lecturer at the Odeion School of Music (OSM) at the University of the Free State (UFS), is in the process of developing an innovative interactive mobile music application – Notes&Fun.

Notes&Fun is being designed to assist aspirant pianists. It will support beginners with notation and rhythmic patterns.

The app will display single notes, phrases or rhythmical patterns on the phone or tablet and then apply the built-in microphone to measure the frequency of the notes played on the piano itself. It will indicate whether you’ve played correctly, or if you have made a mistake, the correct note will be displayed. Notes&Fun consists of multiple levels, each with a practise and test mode that gradually increases in difficulty and complexity. As opposed to existing apps, Notes&Fun is conceptualised with immediate pitch detection and is applied with a real (acoustic) piano.

For the pilot phase of this initiative, the developing company Maxxor in Cape Town will create a demo app which can be downloaded for testing purposes and general feedback. Once the developing company and innovator are satisfied with the first phase, the product will be marketed vigorously on social media. The initial app will be free, but subsequent levels will need to be purchased. The developers will start a Facebook page where users of the app can add their latest scores and compete with other users. Initially the app will only be available on the Google Play Store due to the fact that more people own Android devices than Apple products. Once the product has proven to be financially viable, the developers will adapt it for the Mac App Store as well.

“The beauty of this app is that music has a universal language, so it can be marketed internationally and I am privileged to have the institutional support from the UFS Technology Unit regarding the judicial process and developing process of the product,” Dr De Villiers said.

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